Results 51 to 60 of about 94,283,903 (258)

Analysis of full and partial agonists binding to beta(2)-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

, 2009
The 2.4 angstrom crystal structure of the beta(2)-adrenergic receptor (beta(2)AR) in complex with the high-affinity inverse agonist (-)-carazolol provides a detailed structural framework for the analysis of ligand recognition by adrenergic receptors ...
Abagyan, Ruben, Cherezov, Vadim, Katritch, Vsevolod, Roth, Christopher B., Reynolds, Kimberly A., Hanson, Michael A., Yeager, Mark   +6 more
core   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). [PDF]

, 1987
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists.
Codina, J, Lefkowitz, RJ, Weyand, I, Kühn, H, Caron, MG, Benovic, JL   +5 more
core   +1 more source

Warmed intravenous fluid administration attenuated a reduction in body temperature in anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background Peri‐anaesthetic hypothermia is a well‐documented complication of general anaesthesia and is associated with prolonged recovery, impaired wound healing, and delayed coagulation. Fluid warmers can be used to mitigate heat loss, but there is little evidence supporting their effectiveness in equine anaesthesia.
Miranda P. Starr, Alycia Frampton, Allison Mika, Klaus Hopster, Hope Douglas   +4 more
wiley   +1 more source

Treatment Persistence and Adherence with Overactive Bladder Medications in Taiwan: A Retrospective Database Analysis

European Urology Open Science
Background: Overactive bladder (OAB) is commonly treated with mirabegron or antimuscarinics, but real-world evidence on treatment persistence, adherence, and fall/fracture outcomes in Taiwan remains limited.
Shiau-Han Chen, Chung-Yu Chen, Farid Abdul Hadi   +2 more
doaj   +1 more source

Complication Rates Associated With Evolving Practice Patterns in Vasopressor Use and Fluid Administration for Oral Cavity Cancer Free Flap Reconstruction

Head &Neck, EarlyView.
ABSTRACT Background The safety of vasopressors for managing intraoperative hypotension remains debated. This study evaluated complications associated with vasopressor use and fluid administration in oral cavity cancer free flap surgery. Methods Retrospective review of 826 patients who received oral cavity cancer free flap reconstruction from 2008 to ...
Harrison Gao, Nuwan Dharmawardana, Alex O. Esemezie, Hedyeh Ziai, Philopateer Ataalla, Natalie Weisbrod, Konrado Deutsch, Stuart A. McCluskey, Danny Enepekides, Kevin M. Higgins, Antoine Eskander, John R. de Almeida, David P. Goldstein, Ralph W. Gilbert, Jonathan C. Irish, Dale H. Brown, Christopher M. K. L. Yao, Christopher W. Noel, Sharon Tzelnick   +18 more
wiley   +1 more source

Effects of Concomitant Medications on Clinical and Immunological Outcomes of Cancer Patients Treated With Oncolytic Adenoviruses

International Journal of Cancer, EarlyView.
ABSTRACT Medication taken for other reasons than for the treatment of malignant disease, termed concomitant medication, is known to affect outcomes when used with immune checkpoint inhibitor therapy and other oncological drugs. However, no research in humans has addressed the relationship between concomitant medications and efficacy of oncolytic ...
Santeri A. Pakola, Tatiana V. Kudling, Nea Ojala, James H. A. Clubb, Victor Arias, Elise Jirovec, Mirte van der Heijden, Arianna Eleuteri, Lyna Haybout, Susanna Grönberg‐Vähä‐Koskela, Katriina Jalkanen, Tuomo Alanko, Matthew S. Block, Inge Marie Svane, Anna Kanerva, Otto Hemminki, Dafne C. A. Quixabeira, Claudia Kistler, Suvi Sorsa, Victor Cervera‐Carrascon, Akseli Hemminki   +20 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Inhibition of sequestration of human B-2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells [PDF]

, 2004
Depending on their interaction with intracellular proteins, G proteincoupled receptors (GPCR) often display different affinities for agonists at 37degreesC. Determining the affinity at that temperature is often difficult in intact cells as most GPCRs are
Faussner, Alexander, Jochum, Marianne, Schuessler, Steffen, Seidl, Cornelia   +3 more
core   +1 more source

β3 Receptor Signaling in Pregnant Human Myometrium Suggests a Role for β3 Agonists as Tocolytics

, 2023
Preterm labor leading to preterm birth is the leading cause of infant morbidity and mortality. At the present time, nothing can reliably halt labor once it begins.
Hazik Asif, Scott D. Barnett, Iain L. O. Buxton   +2 more
core   +1 more source