Results 211 to 220 of about 116,135 (274)

Adrenergic Beta Agonists and Anticholinergics in Obstructive Lung Diseases

Journal of Aerosol Medicine, 1997
ABSTRACT Airflow obstruction in chronic obstructive pulmonary disease (COPD) is due to the combination of airway disease and emphysema, may be accompanied by airway reactivity, and may be partially reversible. Aerosol deposition is affected by airway geometry.
ETIENNE LEMARIÉ, PATRICE DIOT
openaire   +2 more sources

Characterization of beta-adrenergic receptors on rat and human osteoblast-like cells and demonstration that beta-receptor agonists can stimulate bone resorption in organ culture

Bone and Mineral, 1993
Charles K Smith, Armen H Tashjian, Edward F Voelkel   +2 more
exaly   +2 more sources

Beta‐agonist Profiling Reveals Novel Biased Signaling Phenotypes for the Beta 2‐adrenergic Receptor with Implications in the Treatment of Asthma

The FASEB Journal, 2022
Asthma is characterized by chronic airway inflammation and airway smooth muscle (ASM) cell contraction. Current treatments for asthma include beta‐agonists which activate the beta 2‐adrenergic receptor, a G protein‐coupled receptor (GPCR) that promotes Gs‐dependent production of cAMP leading to ASM relaxation.
Francesco De Pascali, Michael Ippolito, Emily Wolfe, Konstantine E. Komolov, Nathan Hopfinger, Douglas Lemenze, Roger S. Armen, Steven S. An, Charles P. Scott, Jeffrey L. Benovic   +9 more
openaire   +1 more source

Polymorphisms of Beta2-Adrenergic Receptor Gene in Serbian Asthmatic Adults: Effects on Response to Beta-Agonists

Molecular Diagnosis & Therapy, 2014
Polymorphisms of beta2-adrenergic receptor gene (ADRB2) are clinically relevant for several reasons, including as a risk factor for asthma development/severity and predicting the effectiveness of treatment with beta2-agonists in reducing asthma symptoms. The aim of this study was to examine the association between ADRB2 gene polymorphisms and asthma in
Petrović-Stanojević, Nataša, Topić, Aleksandra, Nikolić, Aleksandra, Stankovic, Marija, Dopuđa-Pantić, Vesna, Milenković, Branislava, Radojković, Dragica   +6 more
openaire   +6 more sources

Association of beta-agonists with corresponding beta 2- and beta 1-adrenergic pentapeptide sequences.

International journal of peptide and protein research, 1993
Synthesized beta 1- and beta 2-pentapeptide sequences corresponding to published adrenoceptor transmembrane activation site subtypes were investigated in vitro for selectivity in association for drug ligands of known selectivity. Both nuclear magnetic resonance spectroscopy and molecular mechanics demonstrated that structural differences among the ...
W F, Schmidt, R M, Waters, A D, Mitchell, J D, Warthen, I L, Honigberg, H, Van Halbeek   +5 more
openaire   +2 more sources

Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1995
Few studies have addressed whether target tissue adrenergic receptors in humans undergo desensitization in response to agonist administration. To determine whether lung cell beta 2-adrenergic receptors (beta 2-AR) undergo such desensitization, we harvested bronchial epithelial cells and alveolar macrophages via bronchoscopy from eight normal subjects ...
J, Turki, S A, Green, K B, Newman, M A, Meyers, S B, Liggett   +4 more
openaire   +2 more sources

Interaction of beta adrenergic agonists and antagonists with brain beta adrenergic receptors in vivo.

Journal of Pharmacology and Experimental Therapeutics, 1987
There is interest in knowing whether beta adrenergic antagonists or agonists, when administered systemically, can enter the brain to interact with central beta adrenergic receptors.
P. Conway, S. Tejani-butt, D. Brunswick
semanticscholar   +1 more source

Effect of the calcium antagonist, diltiazem, on beta-agonist-induced reduction of beta-adrenergic responsiveness in the guinea pig lung

Lung, 1988
This study was designed to clarify the mechanism of tolerance that occurs during prolonged administration of a beta-agonist in relation to membrane phospholipid degradation and to elucidate the effect of diltiazem, a calcium antagonist. Guinea pigs were divided into 3 groups: (1) control--physiological saline (0.5 ml) was injected once a day for 7 ...
F, Taki, K, Hayashi, S, Sugiyama, T, Satake, T, Ozawa   +4 more
openaire   +2 more sources

Desensitization of adenylate cyclase and down regulation of beta adrenergic receptors after in vivo administration of beta agonist.

The Journal of Pharmacology and Experimental Therapeutics, 1982
In vitro incubation of cells with catecholamines leads to both down regulation of beta adrenergic receptor number and desensitization of agonist-stimulated adenylate cyclase activity. These same parameters, down regulation of beta adrenergic receptor number and desensitization of adenylate cyclase activity were assessed in rat lung membranes after in ...
P J, Scarpace, I B, Abrass
openaire   +2 more sources

Effects of ?-agonists on b- and c-waves implicit for adrenergic mechanisms in cat retina

Documenta Ophthalmologica, 1987
Nylidrin (buphenine) is a beta-adrenergic agonist known to dilate peripheral vessels and used therapeutically in retinal degeneration and glaucoma. We studied retinal function under beta-agonists in arterially perfused cat eyes and observed a dose-dependent, reversible increase in b-wave amplitude and a decrease in c-wave amplitude in concentrations ...
Niemeyer G, Cottier D, Gerber U
openaire   +3 more sources