Results 271 to 280 of about 53,199 (316)

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji   +10 more
wiley   +1 more source

Avenanthramide C From Oats Possibly Exerts Anti‐Inflammatory Effects in Human Umbilical Vein Endothelial Cells

open access: yesJournal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Hiroyuki Sasaki   +8 more
wiley   +1 more source

Haemodynamic Changes After Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine Versus Placebo During Induction of General Anaesthesia: A Randomised Trial

open access: yesActa Anaesthesiologica Scandinavica, Volume 70, Issue 1, January 2026.
ABSTRACT Background Ephedrine, phenylephrine, and norepinephrine are commonly used to manage hypotension during the induction of anaesthesia. The objective of this study was to evaluate whether prophylactic administration of assumed equipotent doses of these vasopressors could maintain systolic arterial blood pressure (SAP) and heart rate (HR) within ...
Gunnar Helge Sjøen   +4 more
wiley   +1 more source

Hydrogen Sulfide and Nitric Oxide Improve Renal Function and α-Adrenergic Responsiveness in Rats with Left Ventricular Hypertrophy. [PDF]

open access: yesCurr Issues Mol Biol
Fatima T   +10 more
europepmc   +1 more source

Alcohol and the endocrine system: A critical review of disruptions, potential mechanisms, and health implications

open access: yesAlcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley   +1 more source

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