Results 291 to 300 of about 53,199 (316)
‘BJUI Clinical Dilemma’: the overactive bladder
BJU International, Volume 137, Issue 1, Page 18-25, January 2026.
Oliver Gross +7 more
wiley +1 more source
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The FASEB Journal, 2022
Asthma is characterized by chronic airway inflammation and airway smooth muscle (ASM) cell contraction. Current treatments for asthma include beta‐agonists which activate the beta 2‐adrenergic receptor, a G protein‐coupled receptor (GPCR) that promotes Gs‐dependent production of cAMP leading to ASM relaxation.
Francesco De Pascali +9 more
openaire +1 more source
Asthma is characterized by chronic airway inflammation and airway smooth muscle (ASM) cell contraction. Current treatments for asthma include beta‐agonists which activate the beta 2‐adrenergic receptor, a G protein‐coupled receptor (GPCR) that promotes Gs‐dependent production of cAMP leading to ASM relaxation.
Francesco De Pascali +9 more
openaire +1 more source
Adrenergic Beta Agonists and Anticholinergics in Obstructive Lung Diseases
Journal of Aerosol Medicine, 1997ABSTRACT Airflow obstruction in chronic obstructive pulmonary disease (COPD) is due to the combination of airway disease and emphysema, may be accompanied by airway reactivity, and may be partially reversible. Aerosol deposition is affected by airway geometry.
ETIENNE LEMARIÉ, PATRICE DIOT
openaire +1 more source
Molecular Diagnosis & Therapy, 2014
Polymorphisms of beta2-adrenergic receptor gene (ADRB2) are clinically relevant for several reasons, including as a risk factor for asthma development/severity and predicting the effectiveness of treatment with beta2-agonists in reducing asthma symptoms. The aim of this study was to examine the association between ADRB2 gene polymorphisms and asthma in
Petrović-Stanojević, Nataša +6 more
openaire +6 more sources
Polymorphisms of beta2-adrenergic receptor gene (ADRB2) are clinically relevant for several reasons, including as a risk factor for asthma development/severity and predicting the effectiveness of treatment with beta2-agonists in reducing asthma symptoms. The aim of this study was to examine the association between ADRB2 gene polymorphisms and asthma in
Petrović-Stanojević, Nataša +6 more
openaire +6 more sources
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1995
Few studies have addressed whether target tissue adrenergic receptors in humans undergo desensitization in response to agonist administration. To determine whether lung cell beta 2-adrenergic receptors (beta 2-AR) undergo such desensitization, we harvested bronchial epithelial cells and alveolar macrophages via bronchoscopy from eight normal subjects ...
J, Turki +4 more
openaire +2 more sources
Few studies have addressed whether target tissue adrenergic receptors in humans undergo desensitization in response to agonist administration. To determine whether lung cell beta 2-adrenergic receptors (beta 2-AR) undergo such desensitization, we harvested bronchial epithelial cells and alveolar macrophages via bronchoscopy from eight normal subjects ...
J, Turki +4 more
openaire +2 more sources
The Journal of Pharmacology and Experimental Therapeutics, 1982
In vitro incubation of cells with catecholamines leads to both down regulation of beta adrenergic receptor number and desensitization of agonist-stimulated adenylate cyclase activity. These same parameters, down regulation of beta adrenergic receptor number and desensitization of adenylate cyclase activity were assessed in rat lung membranes after in ...
P J, Scarpace, I B, Abrass
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In vitro incubation of cells with catecholamines leads to both down regulation of beta adrenergic receptor number and desensitization of agonist-stimulated adenylate cyclase activity. These same parameters, down regulation of beta adrenergic receptor number and desensitization of adenylate cyclase activity were assessed in rat lung membranes after in ...
P J, Scarpace, I B, Abrass
openaire +2 more sources
Lung, 1988
This study was designed to clarify the mechanism of tolerance that occurs during prolonged administration of a beta-agonist in relation to membrane phospholipid degradation and to elucidate the effect of diltiazem, a calcium antagonist. Guinea pigs were divided into 3 groups: (1) control--physiological saline (0.5 ml) was injected once a day for 7 ...
F, Taki +4 more
openaire +2 more sources
This study was designed to clarify the mechanism of tolerance that occurs during prolonged administration of a beta-agonist in relation to membrane phospholipid degradation and to elucidate the effect of diltiazem, a calcium antagonist. Guinea pigs were divided into 3 groups: (1) control--physiological saline (0.5 ml) was injected once a day for 7 ...
F, Taki +4 more
openaire +2 more sources