Results 151 to 160 of about 19,951 (230)
The Journal of Physiology, EarlyView.Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus +11 more
wiley +1 more source
Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET). [PDF]
World J UrolHedlund P +4 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Brachial intraarterial infusion of exogenous 17β‐oestradiol augmented endothelial and smooth muscle microvascular vasodilatation in premenopausal but not postmenopausal, females. Abstract Menopause is associated with vascular dysfunction. During the menopausal transition, endogenous oestradiol concentrations diminish.
Gabrielle A. Dillon +7 more
wiley +1 more source
α‐Synuclein in Parkinson's Disease: From Bench to Bedside
Medicinal Research Reviews, Volume 45, Issue 3, Page 909-946, May 2025.ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging element at the crossroads between neuro/immune‐inflammatory responses and neurodegeneration in PD. Several evidence show that pathological α‐syn accumulates in neuronal and non‐neuronal cells (i.e., neurons, microglia, macrophages, skin cells, and intestinal cells ...
Gabriele Bellini +8 more
wiley +1 more source
A New GRK2 Inhibitor for Heart Failure. [PDF]
JACC Basic Transl SciGao C, Song N, Wang Y.
europepmc +1 more source
Medicinal Research Reviews, Volume 45, Issue 3, Page 842-866, May 2025.ABSTRACT At different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia‐inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low‐oxygen environment, including the induction of specific enzymes ...
Luca Filippi +9 more
wiley +1 more source
Dezocine and Addiction: Friend or Foe? [PDF]
Pharmaceuticals (Basel)Childers W, Elokely K, Abou-Gharbia M.
europepmc +1 more source
Andrology, Volume 13, Issue 4, Page 955-967, May 2025.Abstract Background Obesity represents a risk in the development of metabolic and oxidative stress (OS), as well as in male infertility. There is still no pharmacological treatment for obesity‐induced male infertility, but the use of natural antioxidants has been proposed as a treatment.
Vázquez Mendoza Luis Heriberto +4 more
wiley +1 more source
Neural regulation of the thymus: past, current, and future perspectives. [PDF]
Front ImmunolCarpenter RS +3 more
europepmc +1 more source
The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea +2 more
wiley +1 more source