Results 161 to 170 of about 19,951 (230)

Hijacking of the nervous system in cancer: mechanism and therapeutic targets. [PDF]

Mol Cancer
Zhang Y, Liao Q, Wen X, Fan J, Yuan T, Tong X, Jia R, Chai P, Fan X.   +8 more
europepmc   +1 more source

Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo

British Journal of Pharmacology, Volume 182, Issue 9, Page 1975-1988, May 2025.
Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome and obesity. Understanding mechanisms of neurogenic control of white adipose tissue is key to understanding adipose physiology and pathophysiology, though there is limited research exploring this in adipose ...
Kayleigh E. Goddard, Samuel J. Fountain
wiley   +1 more source

T_H17/Treg lymphocyte balance is regulated by beta adrenergic and cAMP signaling. [PDF]

Brain Behav Immun
Lauten TH, Elkhatib SK, Natour T, Reed EC, Jojo CN, Case AJ.   +5 more
europepmc   +1 more source

Probing Native CB2 Receptor Mobility in Plasma Membranes of Living Cells by Fluorescence Recovery After Photobleaching

ChemBioChem, Volume 26, Issue 8, April 14, 2025.
The study investigates CB2 receptor (CB2R) mobility in live cells using the fluorescent probe RO7304924 and fluorescence recovery after photobleaching (FRAP). Results demonstrate the probe‘s efficiency in quantifying receptor diffusion and mobility, with CB2R showing high mobile fractions and diffusion coefficients.
Francesca Ciaramellano, Alessandro Leuti, Alexandrine D. E. Kurtz, Roman Sarott, Matthias Westphal, Patrick Pfaff, Uwe Grether, Erick M. Carreira, Mauro Maccarrone, Sergio Oddi   +9 more
wiley   +1 more source

Massive pheochromocytoma causing adrenal crisis during surgery: a case report and review of the literature. [PDF]

J Med Case Rep
Zeng J, Yang T, Wang Y, Wu L.
europepmc   +1 more source

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Genomic landscape and preclinical models of angiosarcoma

Molecular Oncology, Volume 19, Issue 4, Page 965-983, April 2025.
Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton, Bozhi Liu, Lauren E. Gartenhaus, Jason A. Hanna   +3 more
wiley   +1 more source

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist. [PDF]

Proc Natl Acad Sci U S A
Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R.   +6 more
europepmc   +1 more source

Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells

FEBS Open Bio, Volume 15, Issue 4, Page 634-646, April 2025.
Dexmedetomidine decreases insulin release and affects glucose metabolism; however, the specific mechanism remains largely unknown. This study shows clinically relevant doses of dexmedetomidine suppressed glucose‐stimulated insulin secretion. There was no significant difference in oxygen consumption rate, intracellular ATP levels, or caspase‐3/7 ...
Munenori Kusunoki, Kiichi Hirota, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Mikio Hayashi   +5 more
wiley   +1 more source

[Adrenergic beta-Antagonists in prevention of cardiovascular complications in major non-cardiac surgery].

Kardiologia polska, 2007
openaire   +1 more source