Involvement of S100A8 and S100A9 in nonischaemic cardiomyopathy
Clinical and Translational Discovery, Volume 5, Issue 2, April 2025.1. S100 calcium binding proteins A8 and A9 (S100A8/A9) could be released from bone marrow (BM)‐ and non‐BM‐derived cells. 2. S100A8/A9 mainly activates the Toll‐like receptor 4 (TLR4) and receptors of advanced glycation endproducts (RAGE) signalling pathways and drives mitochondrial dysfunction, inflammation, reactive oxygen species production and ...
Qiu‐Yue Lin +2 more
wiley +1 more source
Autonomic Nervous System: A Therapeutic Target for Cardiac End-Organ Damage in Hypertension. [PDF]
HypertensionGottlieb LA +4 more
europepmc +1 more source
Ecology and Evolution, Volume 15, Issue 4, April 2025.Multi‐omics analysis of gut microbiome and host metabolism in different populations of Chinese alligators (Alligator sinensis) during various reintroduction phases. ABSTRACT Reintroduction plays a significant role in the self‐maintenance and reconstruction of wild animal populations, serving as a communication bridge between captive and wild animals ...
Chong Wang +8 more
wiley +1 more source
Management of patient with acute lymphocytic myocarditis and congenital long QT syndrome presenting with electrical storm and incessant Torsade de Pointes: a case report. [PDF]
J Med Case RepKarwiky G +5 more
europepmc +1 more source
Ecology and Evolution, Volume 15, Issue 4, April 2025.The nonsymbiotic sea anemone Anthopleura nigrescens thrives in the extreme shallow‐water hydrothermal vents off Kueishan Island, Taiwan, where they represent some of the world's most extreme environments. Transcriptomic analyses revealed that genes involved in H2S homeostasis, stress resistance, and DNA repair are enriched in vent populations ...
Mei‐Fang Lin +2 more
wiley +1 more source
A single-center clinical trial evaluating topical propranolol for preventing stress-induced hair loss. [PDF]
FASEB JZhu M +9 more
europepmc +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Causal relationship between antihypertensive drugs and Hashimoto's thyroiditis: a drug-target Mendelian randomization study. [PDF]
Front Endocrinol (Lausanne)Cui B, Chen A, Xu C, Mao C, Chen Y.
europepmc +1 more source
Impact of renin angiotensin system inhibitors on survival of patients with metastatic non-small cell lung cancer. [PDF]
Ann Saudi MedSever N +14 more
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source