Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
ABSTRACT An increasing number of individuals are at high risk of type 2 diabetes (T2DM) and its cardiovascular (CV) complications, which challenges healthcare systems with an increased risk of developing CV diseases. Patients with T2DM exhibit a unique cardiac phenotype termed diabetic cardiomyopathy (DCM).
Adam Russell‐Hallinan+11 more
wiley +1 more source
Atypical development and swift resolution of an ulcerated hemangioma: a case report. [PDF]
Chakhunashvili K+2 more
europepmc +1 more source
The future of pharmacogenetics in the treatment of heart failure [PDF]
Alex S Doney+11 more
core +2 more sources
Recent Developments in the Optical Control of Adrenergic Signaling
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi+4 more
wiley +1 more source
β3‐Adrenoceptor Agonist Effects on the Urinary Bladder Beyond Detrusor Relaxation
ABSTRACT Aims β3‐Adrenoceptor agonists such as mirabegron or vibegron reach pharmacokinetic steady‐state within a few days. However, maximum improvements in symptoms of the overactive bladder syndrome are reached at time points later than 4 weeks, that is, detrusor smooth muscle relaxation cannot fully explain clinical effects.
Martin C. Michel+2 more
wiley +1 more source
Visual Thinking to Explore "Relational Pharmacology": Systemic Maps for Managing Non-Selective Antidepressants in Cardiovascular Prevention. [PDF]
García-Domínguez I+2 more
europepmc +1 more source
Differential mechanisms of action of the trace amines octopamine, synephrine and tyramine on the porcine coronary and mesenteric artery [PDF]
Chess-Williams, Russ+2 more
core +1 more source
The Clinical Significance of the Subtypes of Detrusor Overactivity: A Systematic Review
ABSTRACT Introduction Detrusor overactivity (DO) is the “occurrence of detrusor contraction(s) during filling cystometry” [7] and can be “phasic” or “terminal” [26]. The aim of this systematic review was to establish whether there is any clinical significance between the different subtypes of DO in terms of demographics, underlying pathophysiology ...
Manisha Teji+2 more
wiley +1 more source
Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice. [PDF]
Vas S+5 more
europepmc +1 more source