Results 31 to 40 of about 136,170 (301)

Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice.

PLoS ONE, 2019
Catecholamine excess reflecting an adrenergic overdrive of the sympathetic nervous system (SNS) has been proposed to link to hyperleptinemia in obesity and may contribute to the development of metabolic disorders.
Linh V Nguyen, Quang V Ta, Thao B Dang, Phu H Nguyen, Thach Nguyen, Thi Van Huyen Pham, Trang Ht Nguyen, Stephen Baker, Trung Le Tran, Dong Joo Yang, Ki Woo Kim, Khanh V Doan   +11 more
doaj   +1 more source

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

eLife, 2019
Increased adrenergic tone resulting from cardiovascular stress leads to development of heart failure, in part, through chronic stimulation of β1 adrenergic receptors (βARs) on cardiac myocytes.
Craig A Nash, Wenhui Wei, Roshanak Irannejad, Alan V Smrcka   +3 more
doaj   +1 more source

Prognostic Impact of Concomitant Beta-Blocker Use on Survival in EGFR-Mutant Metastatic Non-Small Cell Lung Cancer Patients Treated with Erlotinib

Medicina
Background and Objectives: Erlotinib, a tyrosine kinase inhibitor (TKI), is an established therapy for patients with metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.
Oğuzhan Yıldız, Talat Aykut, Bahattin Engin Kaya, Ömer Genç, Ali Fuat Gürbüz, Fatih Saçkan, Melek Karakurt Eryılmaz, Mehmet Zahid Koçak, Murat Araz, Mehmet Artaç   +9 more
doaj   +1 more source

Differential effects of adrenergic antagonists (Carvedilol vs Metoprolol) on parasympathetic and sympathetic activity: a comparison of clinical results

Heart International, 2014
Background Cardiovascular autonomic neuropathy (CAN) is recognized as a significant health risk, correlating with risk of heart disease, silent myocardial ischemia or sudden cardiac death.
Heather L. Bloom, Aaron I. Vinik, Joe Colombo   +2 more
doaj   +1 more source

Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients

Scientific Reports, 2021
For pheochromocytoma and sympathetic paraganglioma (PPGL), surgery can be used as a curative treatment; however, the life-threatening risk of perioperative hemodynamic instability (HI) presents challenges.
Jung Hee Kim, Hyung-Chul Lee, Su-jin Kim, Soo Bin Yoon, Sung Hye Kong, Hyeong Won Yu, Young Jun Chai, June Young Choi, Kyu Eun Lee, Kwang-Woong Lee, Seung-Kee Min, Chan Soo Shin, Kyu Joo Park   +12 more
doaj   +1 more source

Electroacupuncture acutely improves cerebral blood flow and attenuates moderate ischemic injury via an endothelial mechanism in mice. [PDF]

PLoS ONE, 2013
Electroacupuncture (EA) is a novel therapy based on traditional acupuncture combined with modern eletrotherapy that is currently being investigated as a treatment for acute ischemic stroke.
Ji Hyun Kim, Kyung Ha Choi, Young Jung Jang, Sun Sik Bae, Byung-Cheul Shin, Byung Tae Choi, Hwa Kyoung Shin   +6 more
doaj   +1 more source

EFFECT OF CARDIOSELECTIVE -BLOCKER OF BISOPROLOL ON PREVENTION OF EFFECTS OF b-ADRENERGIC STIMULATION AND PREVENTION OF CARDIOTOXIC EFFECT OF CATEСOLAMINES IN THERAPY OF CARDIOVASCULAR DISEASE PATIENTS

Медицинский совет, 2016
The articles is devoted to role of the modern selective β-adrenergic blocker bisoprolol in therapy of angina, arterial hypertension, cardiac insufficiency, rhythm disturbance.
V. P. LUPANOV
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Renal- and calcium-dependent vascular effects of Polybia paulista wasp venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
In the present study, the effects of Polybia paulista venom (PPV) on renal and vascular tissues were investigated. Isolated kidneys perfused with PPV (1 and 3 μg/mL) had increased perfusion pressure, renal vascular resistance, urinary flow, and ...
JFC Vinhote, AFC Torres, RT Dantas, TP Praciano, RRPPB Menezes, DF Sousa, TS Brito, FJB Lima, MH Toyama, PJ Magalhães, HSA Monteiro, AMC Martins-Nunes   +11 more
doaj   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source