Results 101 to 110 of about 2,542,862 (407)

Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. [PDF]

, 2002
BackgroundIron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger ...
Chew, Herbert George, Gibbs, Brett Jason, Hearthway, Megan Lesley, Motsko, Madelyne, Mullendore, Michael Eugene, Premo, Daniel Aaron, Sappington, Andrea, Turner, Lexa Rae, Walker, LeeAnn   +8 more
core   +1 more source

Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregulation of IL-6. [PDF]

, 2014
Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined.
Byrne, Barbara A, Gorouhi, Farzam, Granick, Jennifer L, Isseroff, Rivkah R, Kim, Min-Ho, Ramirez, Sandra, Simon, Scott I, Soulika, Athena M   +7 more
core   +2 more sources

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

Nature, 2010
β-adrenergic receptors (βARs) are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins upon binding catecholamine agonist ligands such as adrenaline and noradrenaline.
Tony Warne, R. Moukhametzianov, J. Baker, Rony Nehmé, P. Edwards, A. Leslie, G. Schertler, C. Tate   +7 more
semanticscholar   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

Adverse Effects on β‐Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long‐Term Cardiac Function

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIschemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury. However, the effect of IPC and IPoC on functional recovery following
Rolf Schreckenberg, Péter Bencsik, Martin Weber, Yaser Abdallah, Csaba Csonka, Kamilla Gömöri, Krisztina Kiss, János Pálóczi, Judit Pipis, Márta Sárközy, Péter Ferdinandy, Rainer Schulz, Klaus‐Dieter Schlüter   +12 more
doaj   +1 more source

Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β\u3csub\u3e2\u3c/sub\u3e-agonist use [PDF]

, 2006
Background Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement.
Batra, Vikas, Cirelli, Rosemary, Foster, Gayle C., Hastie, Annette T., Hawkins, Gregory A., Peters, Stephen P., Rybinski, Katherine A., Wu, Min, Zangrilli, James G.   +8 more
core   +1 more source

Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength [PDF]

, 2014
Experimental studies suggest that the β‐blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against bone
Apel, Arai, Aro, Aspenberg, Baek, Bliziotes, Bonnet, Bonnet, Bostrom, Chenu, Cherruau, Chhabra, Ding, Elefteriou, Elefteriou, Graham, Hara-Irie, Harrison, He, Hohmann, Jeyabalan, Kajimura, Kondo, Long, Mach, Madsen, Marenzana, Marsell, Minkowitz, Moran, Morgan, Pierroz, Pullar, Reid, Rodrigues, Serre, Strömberg, Takeda, Takeda, Togari   +39 more
core   +2 more sources

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]

, 2017
Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava, Emanuele C. Latagliata, Giulia Chiacchierini, Luisa Lo Iacono, Luisa Lo Iacono, Marco Sancandi, Stefano Puglisi-Allegra, Stefano Puglisi-Allegra, Valeria Oliva   +8 more
core   +4 more sources