Results 101 to 110 of about 121,835 (341)

Frailty determinants in heart failure: Inflammatory markers, cognitive impairment and psychosocial interaction

open access: yesESC Heart Failure, EarlyView.
Abstract Aims This study aimed to identify factors associated with frailty in heart failure (HF) patients, focusing on demographic, biochemical and health‐related variables. It also explored the correlation between frailty and comorbidities such as malnutrition, cognitive impairment and depression, assessing how these factors interact to influence ...
Marta Wleklik   +6 more
wiley   +1 more source

Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

open access: yesFASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022
Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas   +4 more
wiley   +1 more source

Heart failure decompensation with cardiogenic shock exhibits distinct sequential inflammatory profiles

open access: yesESC Heart Failure, EarlyView.
Abstract Aims The inflammatory profile of cardiogenic shock (CS) after myocardial infarction affects outcomes; however, little is known about the impact of inflammatory changes in CS caused by acute decompensated heart failure (ADHF‐CS). We measured levels of inflammatory cytokines in patients with ADHF‐CS admitted to a cardiac intensive care unit ...
Darshan H. Brahmbhatt   +9 more
wiley   +1 more source

β2-Adrenergic Receptor Activation Suppresses the Rat Phenethylamine Hallucinogen-Induced Head Twitch Response: Hallucinogen-Induced Excitatory Post-synaptic Potentials as a Potential Substrate

open access: yesFrontiers in Pharmacology, 2018
5-Hydroxytryptamine2A (5-HT2A) receptors are enriched in layers I and Va of the rat prefrontal cortex and neocortex and their activation increases the frequency of glutamatergic excitatory post-synaptic potentials/currents (EPSP/Cs) onto layer V ...
Gerard J. Marek   +2 more
doaj   +1 more source

Steroid Receptors and Vertebrate Evolution [PDF]

open access: yesarXiv, 2019
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv  

Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets

open access: yesESC Heart Failure, EarlyView.
Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley   +1 more source

Beta Adrenergic Regulation of Intrapulmonary Arteriovenous Anastomoses in Intact Rat and Isolated Rat Lungs

open access: yesFrontiers in Physiology, 2017
Intrapulmonary arteriovenous anastomoses (IPAVA) allow large diameter particles of venous origin to bypass the pulmonary capillary bed and embolize the systemic arterial circulation.
Melissa L. Bates   +5 more
doaj   +1 more source

Effects of exercise modalities on physical function and quality of life in patients with heart failure: A systematic review and network meta‐analysis

open access: yesESC Heart Failure, EarlyView.
Abstract Aims This study aimed to evaluate the effects of various exercise modalities on physical function and quality of life in individuals with heart failure and to identify the most effective approaches. Methods and results A network meta‐analysis was conducted by searching PubMed, Embase and the Cochrane Library databases.
Jiang‐Ying Li   +5 more
wiley   +1 more source

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