Results 121 to 130 of about 121,835 (341)

The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors

open access: yesAndrology, Volume 11, Issue 2, Page 257-269, February 2023., 2023
Abstract Introduction Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be less responsive than non‐diabetic men.
Axel Alberto Cayetano‐Alcaraz   +4 more
wiley   +1 more source

Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

open access: yesExploration, EarlyView.
The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang   +7 more
wiley   +1 more source

Understanding and treating ejaculatory dysfunction in men with diabetes mellitus

open access: yesAndrology, Volume 11, Issue 2, Page 379-398, February 2023., 2023
Abstract Diabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, with a current prevalence of over 525 million.
Ankit Desai   +4 more
wiley   +1 more source

Allobaculum plays a predominant role in the activation of brown fat tissue by diallyl trisulfide

open access: yesFood Frontiers, EarlyView.
Diallyl trisulfide activates brown adipose tissue and prevents obesity by promoting the relative abundance of Allobaculum in the gut of mice. Oral supplementation of Allobaculum stercoricanis, a primary species in Allobaculum, activates brown adipose tissue and prevents obesity.
Yanzhou Hu   +10 more
wiley   +1 more source

The efficacy of PDE5 inhibitors in diabetic patients

open access: yesAndrology, Volume 11, Issue 2, Page 245-256, February 2023., 2023
Abstract Background Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late 1990s, have proven their efficacy in treating several conditions, predominantly pulmonary hypertension and erectile dysfunction where they remain the first‐line therapeutic option.
Agnieszka Swiecicka
wiley   +1 more source

Structural Basis of the Diversity of Adrenergic Receptors

open access: yesCell Reports, 2019
Summary: Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them.
Lu Qu   +11 more
doaj  

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