Results 181 to 190 of about 116,963 (259)

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Unraveling the nexus in the neuro-neoplastic progression of colorectal cancer: Potential role of β2-adrenergic receptor (β2-AR). [PDF]

J Adv Res
Varghese E, Samuel SM, Hornak S, Kubatka P, Büsselberg D.   +4 more
europepmc   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

An immunohistochemical protocol for visualizing adrenergic receptor subtypes in the rhesus macaque hippocampus. [PDF]

J Neurosci Methods
McDermott KE, Barnes CA.
europepmc   +1 more source

Framework for headache management in pediatric patients with stroke and cerebrovascular lesions: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland, Samuel J. Belfer, Christine K. Fox, Samantha L. Irwin, Rachel Vassar, Ann Oh, Sruthi Ilangovan, Amy A. Gelfand   +7 more
wiley   +1 more source

α_1A-Adrenergic Receptor as a Target for Neurocognition: Cautionary Tale from Nicergoline and Quinazoline Non-Selective Blockers. [PDF]

Pharmaceuticals (Basel)
Perez DM.
europepmc   +1 more source

Frequency and characteristics of multi‐domain autonomic dysfunction in patients with spontaneous intracranial hypotension

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Spontaneous intracranial hypotension (SIH) is caused by leakage of cerebrospinal fluid and often produces symptoms that worsen when standing, which may resemble autonomic disorders (conditions related to blood flow and heart rate).
Woo‐Seok Ha, Da Eun Jung, Sojung Yoon, Joonho Kim, Min Kyung Chu   +4 more
wiley   +1 more source

Chromogranin A deficiency attenuates tauopathy by altering epinephrine-alpha-adrenergic receptor signaling in PS19 mice. [PDF]

Nat Commun
Jati S, Munoz-Mayorga D, Shahabi S, Tang K, Tao Y, Dickson DW, Litvan I, Ghosh G, Mahata SK, Chen X.   +9 more
europepmc   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

β₂-Adrenergic Receptor Agonists in Diabetic Kidney Disease: Exploring a New Frontier. [PDF]

Biochem Res Int
Hegde S, Chogtu B, Magazine R, Magazine R, Prabhu R.   +4 more
europepmc   +1 more source