Results 231 to 240 of about 121,835 (341)

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel, Zeenat Zara, Alessandro Nicoli, Alexandra Steuer, Marta Lopez‐Balastegui, Jana Selent, Sanjai Karanth, Melanie Koehler, Antonella Ciancetta, Layara Akemi Abiko, Franz Hagn, Antonella Di Pizio   +11 more
wiley   +1 more source

Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury. [PDF]

Sci Adv
Jiang R, Lu Z, Wang C, Xiao J, Liu Q, Xu X, Shi J, Shen J, Zhu X, Gong P, Zhuang QX, Shi K, Shi W.   +12 more
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Electroacupuncture alleviates acute myocardial ischemic injury in mice by regulating the β₁ adrenergic receptor and post-receptor protein kinase A signaling pathway. [PDF]

Acupunct Med
Zuo H, Qu Q, Tong Y, Wang L, Wang X, Wu S, Zhou M.   +6 more
europepmc   +1 more source

Antibiotic‐induced decrease of bacterial load in guinea pig intestine reduces α2‐adrenoceptor expression and activity in peristaltic motor inhibition

British Journal of Pharmacology, EarlyView.
Background and Purpose The use of analgosedatives in critically ill patients carries the risk of impairing gastrointestinal (GI) propulsion and could thereby lead to sepsis. The gut microbiota can influence GI motility, but whether GI microbial dysbiosis modifies GI peristalsis impairment by analgosedative drugs has not yet been analysed. This question
Aitak Farzi, Eva Tatzl, Karl Kashofer, Slave Trajanoski, Michael K. Herbert, Peter Holzer   +5 more
wiley   +1 more source

Activation of α2B/2C adrenergic receptor ameliorates ocular surface inflammation through enhancing regulatory T cell function. [PDF]

Mucosal Immunol
Fan NW, Yu M, Wang S, Blanco T, Luznik Z, Chauhan SK, Viswanath V, Gil D, Held K, Chen Y, Dana R.   +10 more
europepmc   +1 more source

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

British Journal of Pharmacology, EarlyView.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia, Belén Climent, Bianca Barreira, Daniel Morales‐Cano, Ana Sánchez, Argentina Fernández, Borja García‐Gómez, Javier Romero‐Otero, Claudia Rodríguez, Laura Moreno, Dolores Prieto, María Jesús Larriba, Angel Cogolludo, Javier Angulo, Francisco Perez‐Vizcaino   +14 more
wiley   +1 more source

Revealing Water-Mediated Activation Mechanisms in the Beta 1-Adrenergic Receptor via OneOPES-Enhanced Free Energy Landscapes

Aureli S, Rizzi V, Piasentin N, Gervasio FL.   +3 more
europepmc   +1 more source

Optical control of cell-surface and endomembrane-exclusive β-adrenergic receptor signaling. [PDF]

J Biol Chem
Thotamune W, Ubeysinghe S, Shrestha KK, Mostafa ME, Young MC, Karunarathne A.   +5 more
europepmc   +1 more source

Intracellular cyclic AMP production enhanced by a hormone receptor transferred from a different cell. beta-adrenergic responses in cultured cells conferred by fusion with turkey erythrocytes

, 1978
Dennis Schulster, Joseph Orly, G. Seidel, M. Schramm   +3 more
openalex   +1 more source