Results 251 to 260 of about 121,835 (341)

Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia

Diabetic Medicine, EarlyView.
Abstract Aims Hypoglycaemia causes abnormal cardiac repolarisation, which has been related to sympathoadrenal activation. We examined whether individuals with type 1 diabetes (T1D) and impaired awareness of hypoglycaemia (IAH) were protected against proarrhythmogenic alterations on their electrocardiogram during clinical episodes of hypoglycaemia ...
Peter Novodvorsky, Alan Bernjak, Ellen Downs, Amelia Smith, Muhammad Fahad Arshad, Andrei I. Oprescu, Richard M. Jacques, Justin Lee, Simon R. Heller, Ahmed Iqbal   +9 more
wiley   +1 more source

Leveraging adrenergic receptor blockade for enhanced nonalcoholic fatty liver disease treatment via a biomimetic nanoplatform. [PDF]

J Nanobiotechnology
Fei B, Zhao Y, Wang J, Wen P, Li J, Tanaka M, Wang Z, Li S.   +7 more
europepmc   +1 more source

Retrospective evaluation of the impact of atropine administration on incidence of post‐operative colic in healthy, isoflurane‐anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background In anaesthetised horses, bradycardia secondary to high vagal tone can reduce cardiac output and blood pressure. The use of anticholinergics in horses is limited due to concerns about ileus and abdominal discomfort. This retrospective study sought to determine the prevalence of post‐operative abdominal discomfort in healthy horses ...
Kelley M. Varner, Alexandra L. Curtiss, Patricia M. Hogan, Kim Love, John R. Dodam   +4 more
wiley   +1 more source

Pan-cancer analysis of the role of α2C-adrenergic receptor (ADRA2C) in human tumors and validation in glioblastoma multiforme models. [PDF]

J Cancer
Zhang X, Chen H, Wang C, Chen C, Liu L, Nie S, Gao X, Huang N, Chen J.   +8 more
europepmc   +1 more source

Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane‐anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg, JoAnn Slack, Darko Stefanovski, DeAnna Theiss, Klaus Hopster   +4 more
wiley   +1 more source

Catecholamines Attenuate LPS-Induced Inflammation through β2 Adrenergic Receptor Activation- and PKA Phosphorylation-Mediated TLR4 Downregulation in Macrophages. [PDF]

Curr Issues Mol Biol
Wang C, Feng GG, Takagi J, Fujiwara Y, Sano T, Note H.   +5 more
europepmc   +1 more source

The universal role of adaptive transcription in health and disease

The FEBS Journal, EarlyView.
Adaptive transcription via molecules such as CREB, MEF2, SRF, AP1, Nr4a1, and Egr1 constitutes a universal mechanism for directed cell state transitions in health and disease. These molecules are involved in physiological adaptation processes, pathological maladaptations, curative adaptations, and development of resistance to treatment.
Thomas Lissek
wiley   +1 more source

Efficacy of repeated immunoadsorption in patients with post-COVID myalgic encephalomyelitis/chronic fatigue syndrome and elevated β2-adrenergic receptor autoantibodies: a prospective cohort study. [PDF]

Lancet Reg Health Eur
Stein E, Heindrich C, Wittke K, Kedor C, Rust R, Freitag H, Sotzny F, Krüger A, Tölle M, Grabowski P, Scheibenbogen C, Kim L.   +11 more
europepmc   +1 more source

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera

The FEBS Journal, EarlyView.
Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin, Aoife Giblin, Aleksandra Judina, Punchita Rujirachaivej, Laura G. Corral, Eliza Glennon, Zhi Xian Tai, Tian Feng, Eduardo Torres, Alina Zorn, Julia Gorelik, Elka Kyurkchieva, Pa Thai Yenchitsomanus, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie   +16 more
wiley   +1 more source

Association between rs4994 variant in β3-Adrenergic receptor and obesity in Vietnamese preschool-age children, independent of eating behaviors. [PDF]

BMC Pediatr
Hanh NTH, Trang DTN, Thu NTT, Tuyet LT.
europepmc   +1 more source