Results 301 to 310 of about 2,542,862 (407)

Effects of vatinoxan on gastrointestinal motility, sedation, and antinociception during and after long‐lasting detomidine infusion in horses

Equine Veterinary Journal, EarlyView.
Abstract Background Sedation in horses is typically achieved using alpha‐2 adrenoceptor agonists, although their use is associated with multiple side effects. A peripheral alpha‐2 adrenoceptor antagonist, vatinoxan, can alleviate many of these. Objectives To evaluate the effects of vatinoxan infusion on gastrointestinal motility, sedation, and ...
Bartlomiej Obrochta, Heidi Tapio, Marja Raekallio, Luis Alfonso Gracia Calvo, Rebecca Rivera Pöyhönen, Kati Hagman, Noora Jantunen, Ninja Karikoski   +7 more
wiley   +1 more source

Systemic alpha-1 adrenergic receptor inhibition reduces sperm damage in adult and aging spontaneously hypertensive rats. [PDF]

Sci Rep
Machado NR, Miyazaki MA, Oliveira TD, Dias KT, Colli LG, Belardin LB, Bertolla RP, Rodrigues SF.   +7 more
europepmc   +1 more source

Aetiological relevance of haematological, biochemical and endocrine parameters on equine odontoclastic tooth resorption and hypercementosis (EOTRH)

Equine Veterinary Journal, EarlyView.
Abstract Background The dental syndrome EOTRH is a painful, progressive dental disease with an unknown aetiology. The often painful nature of EOTRH emphasises the need for a better knowledge of the underlying pathogenic mechanism and risk factors. A comparative analysis of haematological, biochemical and endocrine values in EOTRH‐affected and non ...
Melusine Tretow, Anna M. Hain, Astrid Bienert‐Zeit   +2 more
wiley   +1 more source

β2-Adrenergic Receptor Agonist Clenbuterol Protects Against Acute Ischemia/Reperfusion-Induced Arrhythmia by Regulation of Akt/eNOS/NO/Cx43 Signaling Pathway. [PDF]

Pharmacol Res Perspect
Fu J, Liu L, Fu Q, Zeng X, Yang X.
europepmc   +1 more source

Beta Adrenergic Receptor Binding on Polymorphonuclear Leukocytes in Atopic Dermatitis

, 1979
Stanley P. Galant, Sharon Underwood, Sandra Allred, Jon M. Hanifin   +3 more
openalex   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Dexmedetomidine preconditioning attenuates ferroptosis in myocardial ischemia-reperfusion injury via α2 adrenergic receptor activation. [PDF]

Heliyon
Wang M, Ren Z, Sun X, Li Y, Chen Z.
europepmc   +1 more source

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source

Perirenal Fat in Disease Progression: From Inflammatory Mediator to Therapeutic Target

International Journal of Urology, EarlyView.
ABSTRACT Perirenal fat (PRF), the adipose tissue that encases the kidneys, has long been considered a passive energy reservoir and mechanical buffer. However, emerging evidence has identified PRF as a biologically active visceral fat depot that secretes adipocytokines, inflammatory mediators, and other bioactive molecules, and thereby contributes to ...
Eiji Kashiwagi
wiley   +1 more source