Results 141 to 150 of about 97,035 (258)

Concomitant activation of D₁ dopamine and α_2A adrenergic receptors improves cognition better than methylphenidate in two rodent behavioral tests. [PDF]

Discov Pharm Sci
Bransom L, Bassett AP, Zhou M, Mailman RB, Yang Y.   +4 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Activation of α2-adrenergic receptors as a therapeutic strategy for immune rejection in post-surgery osteosarcoma recurrence treatment. [PDF]

J Orthop Translat
Pei YH, Wang Z, Zheng YS, Wang ZY, Cao CW, Liang HJ, Wang BY, Jin ZJ, Lin SY, Chen LX, Guo W, Xu M.   +11 more
europepmc   +1 more source

Adrenergic receptors [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Central injection of epidermal growth factor (EGF) induces hypophagia via D₁ dopaminergic and β₂ adrenergic receptors in broiler chickens. [PDF]

Poult Sci
Jafari-Ardakan Z, Zendehdel M, Mahdavi K.   +2 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Distinct functions of cardiac β-adrenergic receptors in the T-tubule vs<i>.</i> outer surface membrane. [PDF]

Elife
Madders GWP, Barthé M, Lefebvre F, Langlois E, Lefebvre F, Lechêne P, Dia M, Iturrioz X, Llorens-Cortes C, Ha-Duong T, Moine L, Tsapis N, Fischmeister R.   +12 more
europepmc   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Adrenergic Receptors

, 2017
M. Ciccarelli, D. Sorriento, E. Coscioni, G. Iaccarino, G. Santulli   +4 more
openaire   +2 more sources