Results 131 to 140 of about 130,584 (225)

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Disease-associated adipose browning: current evidence and perspectives. [PDF]

Adipocyte
Zhang X, Han X, Xu J, Li G.
europepmc   +1 more source

The Physiological Significance of TRP and Piezo Channels as Physical Stimulus Sensors in Brown Adipocytes. [PDF]

Cells
Uchida K, Iwase M.
europepmc   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Sclerostin deficiency sensitizes white adipocytes to thermogenic signals that induce beiging in mice. [PDF]

Nat Commun
Choquette GM, Kim SP, Wilkinson KJ, Avelar BC, Pathy S, Li Z, Wu J, Aja S, Thorek DLJ, Wolfgang MJ, Riddle RC.   +10 more
europepmc   +1 more source

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima, Haruko Nakamura, Motokazu Koga, Junka Koyama, Yayoi Kimura, Maya N. Vasishth, Evan Y. Snyder, Masashi Asai, Kenta Sakai, Daiki Masukawa   +9 more
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale. [PDF]

Geriatr Gerontol Int
Mogi M, Liu S, Suzuki Y, Shibata Y, Yamada S.   +4 more
europepmc   +1 more source

Diverse immunological roles of liver‐resident immune cells in liver diseases

Precision Medical Sciences, Volume 15, Issue 1, Page 4-17, March 2026.
Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan, Xinqiang Li, Peng Jiang, Dahong Teng, Jinzhen Cai   +4 more
wiley   +1 more source

The Role of Crosstalk Between the Unfolded Protein Response and Autophagy in Diseases Associated with Sympathetic Nervous System Imbalance: Mechanisms and Therapeutic Perspectives. [PDF]

Int J Mol Sci
Xu B, Yang Y, Wang R.
europepmc   +1 more source

GDF15: Anxiety Signalling From the Adipose Tissue

iNew Medicine, Volume 2, Issue 1, March 2026.
Song‐Yang Zhang
wiley   +1 more source