Results 51 to 60 of about 1,223,943 (215)

Angiogenesis‐associated immune genes as prognostic markers and predictors of immunotherapy response in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
Pancreatic ductal adenocarcinoma exhibits marked angiogenic and immune heterogeneity. We identified 28 angiogenesis‐associated immune genes and developed a seven‐gene AIGScore model comprising FGF2, ADGRB3, MMP2, TYMP, VASH1, VEGFD, and ITGAV. A high AIGScore was associated with poor survival, an immunosuppressive tumor microenvironment, and reduced ...
Qing Chang, Qian Wang, Xiumei Jiang, Yongmei Yang, Ailin Qu   +4 more
wiley   +1 more source

Partial KCNQ1OT1 hypomethylation: A disguised familial Beckwith–Wiedemann syndrome as a sporadic adrenocortical tumor [PDF]

, 2015
Beckwith–Wiedemann syndrome has a wide spectrum of complications such as embryonal tumors, namely adrenocortical tumor. Tumor predisposition is one of the most challenging manifestations of this syndrome.
H'mida Ben-Brahim, Dorra, Sabeur Hammami, Saoussen Trabelsi, Soumaya Mougou, Zakhama, Abdelfattah, Saad, Ali, Trabelsi, Saoussen, Chourabi, Maroua, Guédiche, Mohamed Neji, Marwa Haddaji Mastouri, Hammami, Sabeur, Sassi, Sihem, Dorra H'mida Ben-Brahim, Mohamed Neji Guédiche, Maroua Chourabi, Abdelfattah Zakhama, Moez Gribaa, Haddaji Mastouri, Marwa, Gribaa, Moez, Ali Saad, Mougou, Soumaya, Sihem Sassi   +21 more
core   +1 more source

Minimally Invasive Surgery for Pediatric Adrenal Masses—Report on Four Cases

European Journal of Pediatric Surgery Reports, 2019
The dignity of adrenal masses in children varies from benign lesions like adenoma and ganglioneuroma to malignant tumors like adrenocortical carcinoma and neuroblastoma. Any surgical approach, especially minimally invasive surgery (MIS), requires careful
Ahmed ElHaddad, Christoph Castellani, Erich Sorantin, Martin Benesch, Eva Kampelmühler, Georg Singer, Holger Till   +6 more
doaj   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Asynchronous Rhythm of Steroidogenic Factor 1 and Period Homolog 2 mRNA Expression in Mouse Y1 Adrenocorticol Tumor Cells [PDF]

, 2010
The relationship between the expression of Steroidogenic factor 1 (Sf1) and the circadian-related gene, period homolog 2 (Per2), in the adrenal cortex is still unknown.
Toshihiko Yanase, Kouichirou Sonoda, Taijiro Okabe, Kenji Ohe, Ryoichi Takayanagi, Masatoshi Nomura, Koichi Node, Makoto Akashi, Koichi Oba, Hajime Nawata   +9 more
core  

MicroRNAs as potential biomarkers in adrenocortical cancer: progress and challenges

Frontiers in Endocrinology, 2016
Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited therapeutic options. Over the last decade, pan-genomic analyses of genetic and epigenetic alterations and genome-wide expression profile studies allowed major advances in the ...
Nadia eCHERRADI, Nadia eCHERRADI, Nadia eCHERRADI   +2 more
doaj   +1 more source

Surgical approach to an adrenocortical carcinoma with right atrial extension in a nine-year old male: Our experience

Journal of Pediatric Surgery Case Reports, 2020
Adrenocortical carcinoma with intracaval and intra atrial extension is an extremely rare occurrence in the pediatric population. We report the case of a nine‐year‐old male who presented to our outpatient department with facial swelling, weight gain, and ...
Ayesha Saleem, Sarah Jeelani, Zain Baig, Muhammad Arshad   +3 more
doaj   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Genomics of benign adrenocortical tumors

The Journal of Steroid Biochemistry and Molecular Biology, 2019
Benign adrenocortical adenomas and hyperplasia are relatively common and include a spectrum of distinct entities, which diagnosis depends on the macroscopic aspect and the secretion profile. Recent advances in genomics have proposed high-throughput molecular characterization of adrenal tumors, thereby improving our knowledge on the pathophysiology and ...
Anne, Jouinot, Roberta, Armignacco, Guillaume, Assié   +2 more
openaire   +3 more sources

The role of primary cilia and sonic hedgehog signalling in adrenal development function. [PDF]

, 2012
PhDPrimary cilia are sensory organelles found on most vertebrate cells during interphase. They play key roles in development, cell signalling and cancer, and are involved in signal transduction pathways such as Hh and Wnt signalling.
Cogger, Kathryn
core   +4 more sources