Results 61 to 70 of about 1,223,943 (215)

Large functioning Childhood adrenocortical carcinoma (Case report)

مجلة كلية الطب, 2014
We describe a large functioning non metastasizing ACC in 8 years old boy who presented with a history of precocious puberty noticed by his parents since 3 months .Ultrasound of the abdomen showed a large well defined right suprarenal mass with ...
Jinan A. Jabbar, Qusai A. Fahad
doaj   +1 more source

Histopathological stratification of primary aldosteronism using the CYP11B2 size ratio: first evaluation in clinical routine

Histopathology, EarlyView.
CYP11B2 immunohistochemistry identifies aldosterone‐producing nodules and enables objective subtyping using the B2 ratio (B2R), defined as the size ratio between the largest and second‐largest CYP11B2‐positive nodules. A B2R ≥8.1 indicates classical histology with a dominant lesion and high likelihood of cure, whereas B2R <8.1 reflects non‐classical ...
Adam Stenman, Tim Nilsson, Henrik Falhammar, C. Christofer Juhlin   +3 more
wiley   +1 more source

Angiogenesis and Lymphangiogenesis in the Adrenocortical Tumors

Pathology & Oncology Research, 2017
Adrenocortical tumors (ACT) are common adrenal tumors. The majority of ACTs are non-functioning and benign, while adrenocortical carcinomas (ACC) are rare, usually very aggressive and often metastasized when first diagnosed. Our aim was to assess whether blood and lymph vessel density within ACTs correlate with the malignancy character or tumor ...
Sofia S, Pereira, Madalena M, Costa, Susana G, Guerreiro, Mariana P, Monteiro, Duarte, Pignatelli   +4 more
openaire   +2 more sources

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Large Oncocytic Adrenocortical Tumor with Uncertain Malignant Potential [PDF]

, 2011
Oncocytoma is a neoplasm consisting of oncocytes that is found in the salivary gland, kidney, and thyroid. Adrenocortical oncocytoma is particularly uncommon, and most cases reported are benign and nonfunctioning.
Chang Ki Lee, Won Kyu Park, 양승철, Kyung Hwa Choi, Hyung Ho Lee, Jung Ha Bum, Yoon Jin Cha, Myung Soo Kim, 한웅규, 최경화, Seung Choul Yang, Woong Kyu Han   +11 more
core   +1 more source

Expression of Topoisomerase II Alpha in Canine Colorectal Polyps, Adenomas and Adenocarcinomas

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT With the development and increased accessibility of diagnostic methods in veterinary medicine, the possibilities for early detection of proliferative lesions in the canine large intestine have expanded over the past decade. Since in human medicine, topoisomerase II alpha (Topo IIα) is considered a prognostic and predictive marker in various ...
Joanna Fiedorowicz, Katarzyna Paździor‐Czapula, Paweł Antoni Kołodziejski, Iwona Otrocka‐Domagała   +3 more
wiley   +1 more source

Cytologic, Clinicopathologic, and Histologic Findings in a Dog with a Gallbladder Neuroendocrine Carcinoma and Multiple Endocrinopathies

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 10‐year‐old spayed female Shih Tzu was evaluated for a gallbladder mass incidentally identified during a diagnostic workup for hyperadrenocorticism and persistent hypercalcemia. Diagnostic imaging revealed a vascularized intraluminal gallbladder mass, and cytologic examination showed cohesive clusters of epithelial cells with distinct ...
Sam Wicker, Alexis Johnson, Shelly Olin, Thomas Bevelock, Constance Fazio, Hiroyuki Mochizuki   +5 more
wiley   +1 more source

Peripheral precocious puberty in Li–Fraumeni syndrome: a case report and literature review of pure androgen-secreting adrenocortical tumors

Journal of Medical Case Reports, 2023
Introduction Pure androgen-secreting adrenocortical tumors are a rare but important cause of peripheral precocious puberty. Case presentation Here, we report a pure androgen-secreting adrenocortical tumor in a 2.5-year-old boy presenting with penile ...
Sofie Ryckx, Jean De Schepper, Philippe Giron, Ken Maes, Freya Vaeyens, Kaat Wilgenhof, Pierre Lefesvre, Caroline Ernst, Kim Vanderlinden, Daniel Klink, Frederik Hes, Jesse Vanbesien, Inge Gies, Willem Staels   +13 more
doaj   +1 more source

Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To determine the use of resting serum cortisol concentration as a marker of outcome and illness severity as assessed by the Acute Patient Physiologic and Laboratory Evaluation (APPLE) full and fast scores in critically ill dogs with and without systemic inflammatory response syndrome (SIRS).
Andreza Conti‐Patara, Linda G. Martin
wiley   +1 more source

Aldosterone-Producing Adrenocortical Carcinoma with Co-Secretion of Cortisol and Estradiol: A Case Report

Journal of the ASEAN Federation of Endocrine Societies, 2018
Aldosterone-producing adrenocortical carcinoma comprises less than 7% of all functioning adrenocortical carcinomas. We report a rare case of adrenocortical carcinoma with a clinical picture of primary aldosteronism and subclinical Cushing’s syndrome and ...
Karen Lazaro, Perie Adorable-Wagan
doaj