Results 81 to 90 of about 454,704 (201)

Adrenocorticotropic hormone gel for patients with non-infectious uveitis

American Journal of Ophthalmology Case Reports, 2019
Purpose: To describe the potential role of adrenocorticotropic hormone (ACTH) gel treatment in patients with chronic non-infectious uveitis. Observations: We report the clinical course of three patients with bilateral, non-infectious anterior and ...
Yael Sharon, David S. Chu
doaj   +1 more source

The Scoop on Honey Badger Poop: Validation of a Non‐Invasive Method for Assessing Physiological Responses in Captivity

Zoo Biology, EarlyView.
ABSTRACT Captive honey badgers (Mellivora capensis) are routinely exposed to environmental and husbandry‐related stressors that differ markedly from their natural conditions; however, physiological welfare assessments in this species remain limited. This study aimed to validate a non‐invasive approach to evaluate stress‐related fecal glucocorticoid ...
Megan Hutson, André Ganswindt, Andrea B. Webster   +2 more
wiley   +1 more source

Sex‐Specific Involvement of Gut Microbiota in Behavioral and Endocrine Responses to Chronic Predator Odor in Brandt's Voles

Integrative Zoology, EarlyView.
18 days of predator odor exposure altered gut microbiota, increased anxiety‐like behaviors, and elevated hypothalamic–pituitary–adrenal axis activity in Brandt's voles, with males showing behavioral habituation and females remaining sensitive. Cecal microbiota transplantation experiments confirmed that only female recipients of microbiota from predator‐
Chen Gu, Ruiping Xu, Baofa Yin, Ruiyong Wu, Youheng Wei, Dehua Wang, Wanhong Wei   +6 more
wiley   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

A secretagogin locus of the mammalian hypothalamus controls stress hormone release [PDF]

, 2015
This work was supported by the Swedish Research Council (T.Ha., T.Hö.), Hjärnfonden (T.Ha.), the Petrus and Augusta Hedlunds Foundation (T.Ha., T.Hö.), the Novo Nordisk Foundation (T.Ha., T.Hö.), Karolinska Institutet (T.Hö.), the Medical University of ...
Marc Landry, Alpár, Alán, Robert Schnell, Botting, Catherine H., André Calas, Shirran, Sally Lorna, Miklós Palkovits, Fuszard, Matthew Alexander, Wagner, Ludwig, Fuszard, Matthew, Zhang, Ming-Dong, Árpád Dobolyi, Jan Mulder, Catherine H Botting, Sten Linnarsson, Tibor Harkany, Lauren Spence, Spence, Lauren, Harkany, Tibor, Sally L Shirran, Matthew Fuszard, Uhlen, Mathias, Hökfelt, Tomas, Landry, Marc, Shirran, Sally L., Martens, Henrik, Amit Zeisel, Mathias Uhlen, Romanov, Roman A., Botting, Catherine Helen, Tomas Hökfelt, Calas, André, Oláh, Márk, Alán Alpár, Harald H Sitte, Linnarsson, Sten, Márk Oláh, Henrik Martens, Roman A Romanov, Schnell, Robert, Ming‐Dong Zhang, Ludwig Wagner, Sitte, Harald H., Uhlén, Mathias,, Dobolyi, Árpád, Zeisel, Amit, Mulder, Jan, Palkovits, Miklós, Fuszard, M, Zhang, M-D, Landry, M, Schnell, R,, Shirran, SL, Dobolyi, A, Romanov, RA, Alpar, A, Zeisel, A,, Calas, A, Shirran, Sally Lorna; id_orcid   +58 more
core   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Cortisol Cutoffs for Adrenal Insufficiency Using Elecsys II: A Systematic Review

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Adrenal insufficiency (AI) is associated with increased risk of morbidity and mortality if improperly managed. Adrenocorticotrophin (ACTH) stimulation testing is the most widely used AI diagnostic test. Historically, a serum cortisol threshold of 500 nmol/L (18.1 µg/dL), derived using polyclonal assays, was widely used.
Sarah Haunton, Nicola Leppinen, Heather MacDonald, Rebecca A. Tobin, Raoul Rooman, Leanne M. Ward, Alexandra Ahmet, Utkarsh J. Dang   +7 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Effects of Exhaustion and Calcium Supplementation on Adrenocorticotropic Hormone and Cortisol Levels in Athletes

, 2009
The present study was performed to investigate the effects of strenuous exercise and calcium supplementation on cortisol and adrenocorticotropic hormone levels in athletes at rest and exhaustion.
Moğulkoç, Rasim, Çınar, Vedat, Çakmakçı, Oktay, Baltacı, Abdülkerim Kasım   +3 more
core   +1 more source

Adrenocorticotropic Hormone-Independent Cushing Syndrome with Bilateral Cortisol-Secreting Adenomas [PDF]

, 2013
A 48-year-old woman was incidentally found to have bilateral adrenal masses, 2.8 cm in diameter on the right, and 2.3 cm and 1.7 cm in diameter on the left, by abdominal computed tomography.
Ye An Kim, Sang Wan Kim, Jae Hyun Bae, A Ram Hong, Eu Jeong Ku, Mee Soo Chang   +5 more
core   +1 more source