Results 21 to 30 of about 11,146 (212)

Disturbed flow–induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis

JCI Insight, 2020
Atherosclerosis develops preferentially in areas of the arterial system, in which blood flow is disturbed. Exposure of endothelial cells to disturbed flow has been shown to induce inflammatory signaling, including NF-κB activation, which leads to the ...
Akiko Nakayama, Julián Albarrán-Juárez, Guozheng Liang, Kenneth Anthony Roquid, András Iring, Sarah Tonack, Min Chen, Oliver J. Müller, Lee S. Weinstein, Stefan Offermanns   +9 more
doaj   +1 more source

Adrenomedulline improves ischemic left colonic anastomotic healing in an experimental rodent model

Clinics, 2011
BACKGROUND: Leakage from colonic anastomosis is a major complication causing increased mortality and morbidity. Ischemia is a well-known cause of this event.
Oguzhan Karatepe, Idris Kurtulus, Orhan Yalcin, Muharrem Battal, Gulcin Kamali, Timucin Aydin   +5 more
doaj   +1 more source

Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)

Biomolecules, 2020
Recently, the stabilization of the endothelium has been explicitly identified as a therapeutic goal in coronavirus disease 2019 (COVID-19). Adrecizumab (HAM8101) is a first-in-class humanized monoclonal anti-Adrenomedullin (anti-ADM) antibody, targeting ...
Mahir Karakas, Dominik Jarczak, Martin Becker, Kevin Roedl, Marylyn M. Addo, Frauke Hein, Andreas Bergmann, Jens Zimmermann, Tim-Philipp Simon, Gernot Marx, Marc Lütgehetmann, Axel Nierhaus, Stefan Kluge   +12 more
doaj   +1 more source

Adrenomedullin Expression Characterizes Leukemia Stem Cells and Associates With an Inflammatory Signature in Acute Myeloid Leukemia

Frontiers in Oncology, 2021
Adrenomedullin (ADM) is a hypotensive and vasodilator peptide belonging to the calcitonin gene-related peptide family. It is secreted in vitro by endothelial cells and vascular smooth muscle cells, and is significantly upregulated by a number of stimuli. 
Giorgia Simonetti, Davide Angeli, Elisabetta Petracci, Eugenio Fonzi, Susanna Vedovato, Alessandra Sperotto, Antonella Padella, Martina Ghetti, Anna Ferrari, Valentina Robustelli, Valentina Robustelli, Rosa Di Liddo, Maria Teresa Conconi, Cristina Papayannidis, Claudio Cerchione, Michela Rondoni, Annalisa Astolfi, Annalisa Astolfi, Emanuela Ottaviani, Giovanni Martinelli, Michele Gottardi   +20 more
doaj   +1 more source

Adrenomedullin protects rat dorsal root ganglion neurons against doxorubicin-induced toxicity by ameliorating oxidative stress [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Despite effective anticancer effects, the use of doxorubicin (DOX) is hindered due to its cardio and neurotoxicity. The neuroprotective effect of adrenomedullin (AM) was shown in several studies.
Amir Mahmoodazdeh, Sayed Mohammad Shafiee, Mohsen Sisakht, Zahra Khoshdel, Mohammad Ali Takhshid   +4 more
doaj   +1 more source

Effect of intracerebroventricular (ICV) injection of adrenomedullin and its interaction with NPY and CCK pathways on food intake regulation in neonatal layer-type chicks

Poultry Science
: Adrenomedullin has various physiological roles including appetite regulation. The objective of present study was to determine the effects of ICV injection of adrenomedullin and its interaction with NPY and CCK receptors on food intake regulation.
Maryam Soleymani Zahed, Samad Alimohammadi, Shahin Hassanpour   +2 more
doaj   +1 more source

Prognostic value of biomarkers after cardiopulmonary bypass in pediatrics: The prospective PANCAP study.

PLoS ONE, 2019
ObjectiveTo assess the usefulness of procalcitonin, pro-adrenomedullin and pro-atrial natriuretic peptide as predictors of need for mechanical ventilation and postoperative complications (need for inotropic support and bacterial infection) in critically ...
Sara Bobillo-Perez, Iolanda Jordan, Patricia Corniero, Monica Balaguer, Anna Sole-Ribalta, Maria Esther Esteban, Elisabeth Esteban, Francisco Jose Cambra   +7 more
doaj   +1 more source

Effects of enrichment strategies on outcome of adrecizumab treatment in septic shock: Post-hoc analyses of the phase II adrenomedullin and outcome in septic shock 2 trial

Frontiers in Medicine, 2022
PurposeAdrecizumab, a non-neutralizing antibody of adrenomedullin (ADM) was recently investigated regarding its potential to restore endothelial barrier function in septic shock patients with high plasma ADM levels.
Dirk van Lier, Adrien Picod, Gernot Marx, Pierre-François Laterre, Oliver Hartmann, Claudia Knothe, Feriel Azibani, Joachim Struck, Karine Santos, Jens Zimmerman, Andreas Bergmann, Andreas Bergmann, Alexandre Mebazaa, Alexandre Mebazaa, Peter Pickkers   +14 more
doaj   +1 more source

Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver [PDF]

, 2010
Donor organ damage caused by cold preservation is a major problem affecting liver transplantation. Cold preservation most easily damages liver sinusoidal endothelial cells (LSECs), and information about the molecules modulating LSECs function can provide
Kamiyoshi, Akiko, Shindo, Takayuki, Yoshizawa, Takahiro, Tagawa, Yoh-ichi, Iinuma, Nobuyoshi, Arai, Takuma, Koyama, Teruhide, Ichikawa-Shindo, Yuka, Kawate, Hisaka, Miyagawa, Shinichi, Sakurai, Takayuki, Uetake, Ryuichi, Muto, Shin-ichi   +12 more
core   +1 more source

Adrenomedullin Improves Cardiac Remodeling and Function in Obese Rats with Hypertension

Pharmaceuticals, 2022
This study aimed to determine whether adrenomedullin (ADM, 7.2 μg/kg/day, ip), an important endogenous active peptide, has a protective role in cardiac remodeling and function in obesity-related hypertension (OH) rats.
Pei Qian, Qian Wang, Fang-Zheng Wang, Hang-Bing Dai, Hong-Yu Wang, Qing Gao, Hong Zhou, Ye-Bo Zhou   +7 more
doaj   +1 more source