Peritoneal washing cytology in an adult granulosa cell tumor: A case report and review of literature
Journal of Cytology, 2013 Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors. In AGCT, at the time of peritoneal washing, tumor cells are rarely seen to exfoliate and FIGO stage is raised from IA/IB or IIA/IIB to stage ...
Alev O Atilgan +3 more
doaj +1 more source
The tyrosine kinase inhibitor sunitinib affects ovulation but not ovarian reserve in mouse: A preclinical study [PDF]
, 2016 The aim of the study was to evaluate ovarian toxicity of tyrosine kinase inhibitor (TKI) sunitinib, since only scarce data are available on gonadal function after this treatment.
Bernard, V. (Valérie) +7 more
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Aging Cell, Volume 25, Issue 2, February 2026.A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Sainan Zhang +14 more
wiley +1 more source
Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells [PDF]
, 2017 Objective. Resistance to standard chemotherapy poses a major clinical problem in the treatment of ovarian cancer patients. Adult-type granulosa cell tumor (AGCT) is a unique ovarian cancer subtype for which efficient treatment options are lacking in ...
Aittokallio, Tero +15 more
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British Journal of Pharmacology, Volume 183, Issue 4, Page 945-956, February 2026.Ageing brings about various biochemical, structural and mechanical alterations within tissues, profoundly impacting cellular behaviour and function. One of the hallmark changes observed with ageing is an increase in cellular microenvironment stiffness, a biomechanical property influenced by intrinsic factors within the cell and extrinsic factors from ...
Wang HaiYang +3 more
wiley +1 more source
hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li +8 more
wiley +1 more source
Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis
Gynecologic Oncology Reports, 2019 Background: Various ovarian neoplasms may show histological findings that are morphologically indistinguishable from adult granulosa cell tumor (AGCT).
Emily R. Rosen +3 more
doaj +1 more source
Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function [PDF]
, 2000 The recent unraveling of structures of genes for the gonadotropin subunits and gonadotropin receptors has provided reproductive endocrinologists with new tools to study normal and pathological functions of the hypothalamic ...
Huhtaniemi, I.T., Themmen, A.P.N. (Axel)
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The molecular mechanism of ovarian granulosa cell tumors
Journal of Ovarian Research, 2018 Over these years, more and more sex cord-stromal tumors have been reported. Granulosa cell tumor (GCT) is a rare tumor in ovaries, accounts for 2% to 5% of ovarian cancers.
Jiaheng Li +3 more
doaj +1 more source
The Role of WT1 in Embryonic Development and Normal Organ Homeostasis. [PDF]
, 2016 The Wilms' tumor suppressor gene 1 (Wt1) is critically involved in a number of developmental processes in vertebrates, including cell differentiation, control of the epithelial/mesenchymal phenotype, proliferation, and apoptosis.
Muñoz-Chapuli, Ramon, Wilm, Bettina
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