Results 1 to 10 of about 4,287 (134)

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation. [PDF]

Adv Sci (Weinh)
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Y, Yu L, Zhang W, Wessel G, Chen R, Hu W, Xu D.   +6 more
europepmc   +2 more sources

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs. [PDF]

FASEB J
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Mousseron L, Chousianiti D, Poulat F, Legois B, Veitia RA, Todeschini AL.   +5 more
europepmc   +2 more sources

Differential Gene Expression of Mesenchymal Stromal Cell and Granulosa Cell Markers in Equine Follicular Aspirates. [PDF]

Reprod Domest Anim
ABSTRACT Equine follicular aspirates obtained during ovum pick‐up contain a heterogeneous mixture of mesenchymal stromal cells (MSC) and granulosa cells (GC). This study evaluates how selective isolation and expansion of MSC decrease GC populations.
Soriano-Campos MDP, Muñoz-García CC, Luis-Calero M, Del Olmo-Ortiz M, Gallardo-Soler A, Macías-García B, González-Fernández L.   +6 more
europepmc   +2 more sources

FOXL2 + cancer-associated fibroblasts enhances epithelial ovarian cancer development via TGFβ/Smad signaling [PDF]

BMC Cancer
Background FOXL2, a key regulator of ovarian development, is linked to ovarian disorders, but its role in epithelial ovarian cancer (EOC) remains unclear.
Lei Zhao, Jingqi Nie, Jinming Wang, Dongliang Li, Xuewei Hao   +4 more
doaj   +2 more sources

Hyperandrogenism in polycystic ovary syndrome augments Estrogen synthesis through AR-FOXL2–mediated activation of the aromatase gene in granulosa cells [PDF]

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is a complex disorder characterized by various reproductive, metabolic, and endocrine abnormalities. Hyperandrogenism is a key feature of PCOS that significantly impacts ovarian function.
Yi-Ru Tsai, Yen-Nung Liao, Cheng-Ju Tsai, Yu-Ang Lee, Shih-Min Hsia, Kuo-Chung Lan, Hong-Yo Kang   +6 more
doaj   +2 more sources

Identification of a novel FOXL2 mutation in a fourth-generation Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome [PDF]

International Journal of Ophthalmology, 2021
AIM: To characterize the genetic causes and clinical features in a four-generation Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES).
Wei-Ning Rong, Mei-Jiao Ma, Wei Yang, Shi-Qin Yuan, Xun-Lun Sheng   +4 more
doaj   +1 more source

Forkhead box L2 is a target of miR‐133b and plays an important role in the pathogenesis of non‐small cell lung cancer

Cancer Medicine, 2023
Background Forkhead box L2 (FOXL2) has been recognized as a transcription factor in the progression of many malignancies, but its role in non‐small cell lung cancer (NSCLC) remains unclear.
Juan Li, Lirong Gao, Anqi Wang, Huiwen Qian, Jianjie Zhu, Shundong Ji, Jun Chen, Zeyi Liu, Cheng Ji   +8 more
doaj   +1 more source

The transcriptional targets of mutant FOXL2 in granulosa cell tumours. [PDF]

PLoS ONE, 2012
BACKGROUND: Despite their distinct biology, granulosa cell tumours (GCTs) are treated the same as other ovarian tumours. Intriguingly, a recurring somatic mutation in the transcription factor Forkhead Box L2 (FOXL2) 402C>G has been found in nearly all ...
Roseanne Rosario, Hiromitsu Araki, Cristin G Print, Andrew N Shelling   +3 more
doaj   +1 more source

Cooperative effects of oocytes and estrogen on the forkhead box L2 expression in mural granulosa cells in mice

Scientific Reports, 2022
Forkhead box L2 (FOXL2) plays a critical role in the development and function of mammalian ovaries. In fact, the causative effects of FOXL2 misregulations have been identified in many ovarian diseases, such as primary ovarian insufficiency and granulosa ...
Haruka Ito, Chihiro Emori, Mei Kobayashi, Natsumi Maruyama, Wataru Fujii, Kunihiko Naito, Koji Sugiura   +6 more
doaj   +1 more source

Identification and functional analyses of a novel FOXL2 pathogenic variant causing blepharophimosis, ptosis, and epicanthus inversus syndrome [PDF]

International Journal of Ophthalmology, 2023
AIM: To discover the molecular pathogenic basis of the blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), and to predict the clinical subtype according to in vitro experiments, which is significant to the prognosis.
Yu-Cheng Yan, Lu Zhou, Jin-Cai Fan
doaj   +1 more source