Results 11 to 20 of about 5,621 (166)

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target

JCI Insight, 2020
Granulosa cell tumors (GCT) are rare ovarian malignancies. Due to the lack of effective treatment in late relapse, there is a clear unmet need for novel therapies.
Stefano Pierini, Janos L. Tanyi, Fiona Simpkins, Erin George, Mireia Uribe-Herranz, Ronny Drapkin, Robert Burger, Mark A. Morgan, Andrea Facciabene   +8 more
doaj   +2 more sources

The transcription factor FOXL2 in ovarian function and dysfunction.

Folia Histochemica et Cytobiologica, 2010
The Blepharophimosis Ptosis Epicanthus-inversus Syndrome is a genetic disease characterized by complex eyelid malformations often associated with premature ovarian failure (POF).
Elfride De Baere, Marc Fellous, Reiner A Veitia   +2 more
doaj   +2 more sources

Transcriptome sequencing revealed that knocking down FOXL2 affected cell proliferation, the cell cycle, and DNA replication in chicken pre-ovulatory follicle cells.

PLoS ONE, 2020
Forkhead box L2 (FOXL2) is a single-exon gene encoding a forkhead transcription factor, which is mainly expressed in the ovary, eyelids and the pituitary gland. FOXL2 plays an essential role in ovarian development.
Wei Luo, Lantao Gu, Jinqiu Li, Yanzhang Gong   +3 more
doaj   +1 more source

FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells. [PDF]

PLoS ONE, 2014
Aberrant ovarian granulosa cell proliferation and apoptosis may lead to granulosa cell tumors (GCT), the pathogenesis of which involves transcription factors GATA4, FOXL2, and SMAD3. FOXL2 gene harbors a point mutation (C134W) in a vast majority of GCTs.
Mikko Anttonen, Marjut Pihlajoki, Noora Andersson, Adrien Georges, David L'hôte, Sanna Vattulainen, Anniina Färkkilä, Leila Unkila-Kallio, Reiner A Veitia, Markku Heikinheimo   +9 more
doaj   +1 more source

Transcription factors foxl2 and foxl3 regulate cyp19a1a and cyp11b in orange-spotted grouper (Epinephelus coioides)

Aquaculture Reports, 2022
In orange-spotted grouper (E. coioides), the transcription factors foxl2 and foxl3 are thought to play an important role in ovarian and testicular development, but how they do so remains unclear.
Chunli Zhang, Qi He, Huitao Cheng, Lihua Li, Xinhe Ruan, Xuzhuo Duan, Fengqi Huang, Huirong Yang, Haifa Zhang, Herong Shi, Qing Wang, Huihong Zhao   +11 more
doaj   +1 more source

SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies. [PDF]

PLoS ONE, 2011
BACKGROUND: FOXL2 is a transcription factor essential for ovarian development and maintenance. It is mutated in the genetic condition called Blepharophimosis Ptosis Epicantus inversus Syndrome (BPES) and in cases of isolated premature ovarian failure. We
Adrien Georges, Bérénice A Benayoun, Mara Marongiu, Aurélie Dipietromaria, David L'Hôte, Anne-Laure Todeschini, Jana Auer, Laura Crisponi, Reiner A Veitia   +8 more
doaj   +1 more source

Expression levels of FoxL2 and other ovarian genes after FoxL2 knock-down.

, 2023
Expression levels of FoxL2 and Vtg genes at 2, 4, and 6 d post-injection (dsRNA-FoxL2) were analyzed using three replicates. The symbol * indicates a significant difference between sample groups, p-value < 0.05.
Wilaiwan Chotigeat (540109), Wutthipat Potiyanadech (17138085), Chaturawit Choomee (17138088)   +2 more
core   +1 more source

Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Journal of Ovarian Research, 2010
Background The Foxl2 transcription factor is required for ovarian function during follicular development. The mechanism of Foxl2 regulation of this process has not been elucidated.
Escudero Jean M, Haller Jodi L, Clay Colin M, Escudero Kenneth W   +3 more
doaj   +1 more source

The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.

PLoS ONE, 2010
The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure.
Mara Marongiu, Manila Deiana, Alessandra Meloni, Loredana Marcia, Alessandro Puddu, Antonio Cao, David Schlessinger, Laura Crisponi   +7 more
doaj   +1 more source

Associations between forkhead box l2 expression and ovary development in laying hens [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
Make sure healthy ovary or follicle is critical for extending egg laying performance in poultry. Transcription factor forkhead box L2 (FOXL2) gene have key role in regulate development of ovary.
Shouping ZHANG, Xiaojing XIA, Lirong WANG, Renfeng LI, Meng YANG, Sanhu WANG   +5 more
doaj   +1 more source