Results 31 to 40 of about 5,621 (166)

Foxl2 function in ovarian development

, 2006
Foxl2 is a forkhead transcription factor essential for proper reproductive function in females. Human patients carrying mutations in the FOXL2 gene display blepharophimosis/ptosis/epicanthus inversus syndrome (BPES), an autosomal dominant disease ...
Uhlenhaut, N.H., Treier, M.
core   +1 more source

MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2 [PDF]

, 2013
Forkhead L2 (Foxl2) is expressed in ovarian granulosa cells and participates in steroidogenesis by transcriptionally regulating target genes such as steroidogenic acute regulatory protein (StAR) and CYP19A1.
Fang, Ting, Jiang, Yue, Yan, Guijun, Wu, Shaogen, Zhang, Qun, Dai, Anyi, Ding, Lijun, Hu, Yali, Sun, Haixiang   +8 more
core   +1 more source

FOXL2 is a new progesterone-regulated gene in the endometrium

, 2015
National audienceIn mammals, mutual actions of estrogens and progesterone on their uterine receptors are essential for endometrium receptivity and conceptus implantation.
Eozenou, Caroline, Vaiman, Daniel, Charpigny, Gilles, Shimizu, Takashi, Sheldon, Martin, Lesage Padilla, Audrey, Oudin, Jean-Francois, Myamoto, Akio, Pannetier, Maëlle, Reinaud, Pierrette, P., Sandra, Olivier, Healey, Gareth   +11 more
core   +3 more sources

Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors. [PDF]

PLoS ONE, 2013
The etiology of granulosa cell tumors (GCTs) is largely unknown. The primary mode of treatment is surgical, however not all women are cured by surgery alone.
Jung-Chien Cheng, Christian Klausen, Peter C K Leung   +2 more
doaj   +1 more source

Screening and Identification of Transcription Factors Potentially Regulating Foxl2 Expression in Chlamys farreri Ovary

Biology, 2022
Foxl2 is an evolutionarily conserved female sex gene, which is specifically expressed in the ovary and mainly involved in oogenesis and ovarian function maintenance.
Shutong Fan, Xixi Li, Siyu Lin, Yunpeng Li, Huixin Ma, Zhifeng Zhang, Zhenkui Qin   +6 more
doaj   +1 more source

The forkhead factor FOXL2: A novel tumor suppressor?

, 2009
International audienceFOXL2 is a gene encoding a forkhead transcription factor, whose germline mutations are responsible for the blepharophimosis ptosis epicanthus inversus syndrome. We have previously shown that expression levels of FOXL2 in a series of
Sultan, Charles, Benayoun, Bérénice A, Kalfa, Nicolas, Veitia, Reiner A   +3 more
core   +1 more source

FOXL2: a Gene Central to Ovarian Function

, 2023
The FOXL2 (forkhead box L2) gene is located on chromosome 3 and encodes for forkhead box (FOX) family of transcription factors which play a critical role in various biological processes.
Mubeen, Aysha, Parra-Herran, Carlos
core  

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. [PDF]

PLoS ONE, 2017
BACKGROUND:Adult-type granulosa cell tumors of the ovary (aGCTs) are rare tumors that represent 2-5% of ovarian malignancies. The prognosis of this tumor is favorable, and it is characterized by slow progression.
Satoshi Yanagida, Michael S Anglesio, Tayyebeh M Nazeran, Amy Lum, Momoko Inoue, Yasushi Iida, Hirokuni Takano, Takashi Nikaido, Aikou Okamoto, David G Huntsman   +9 more
doaj   +1 more source

Histological Characterization and Comparative Transcriptomic Analysis of Gonads During Early Sex Differentiation in the Northern Snakehead (Channa argus)

Animal Research and One Health, EarlyView.
This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun, Donglei Sun, Haishen Wen, Xin Qi, Chao Li, Xiaoyan Zhang, Yun Li   +6 more
wiley   +1 more source