Results 21 to 30 of about 5,621 (166)

Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium

Reproductive Biology and Endocrinology, 2018
Background Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its levels fluctuate during pregnancy.
Michal Elbaz, Ron Hadas, Louise M. Bilezikjian, Eran Gershon   +3 more
doaj   +1 more source

The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells. [PDF]

PLoS ONE, 2013
Forkhead box L2 (Foxl2), a member of the forkhead transcription factor family, plays important roles in pituitary follicle-stimulating hormone synthesis and in ovarian maintenance and function. Mutations in the human FOXL2 gene cause eyelid malformations
Stella Tran, Ying Wang, Pankaj Lamba, Xiang Zhou, Ulrich Boehm, Daniel J Bernard   +5 more
doaj   +1 more source

Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter.

PLoS ONE, 2010
BackgroundGranulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GCT ...
Nicholas I Fleming, Kevin C Knower, Kyren A Lazarus, Peter J Fuller, Evan R Simpson, Colin D Clyne   +5 more
doaj   +1 more source

New STAT3-FOXL2 pathway and its function in cancer cells

BMC Molecular and Cell Biology, 2019
Background The forkhead transcription factor (FOXL2) plays a crucial role in blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), sex determination, ovary growth and development, and cell cycle regulation.
Yangyang Han, Jun Wu, Weiwei Yang, Di Wang, Tianliang Zhang, Min Cheng   +5 more
doaj   +1 more source

Ovarian Reserve and ART Outcomes in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Patients With FOXL2 Mutations

Frontiers in Endocrinology, 2022
ObjectiveTo characterize the status of ovarian reserve and ART outcomes in BPES women and provide informative reference for clinical diagnosis and treatment.MethodsTwenty-one women with BPES were screened for mutations in the FOXL2 gene and underwent ...
Tingting Meng, Tingting Meng, Tingting Meng, Tingting Meng, Tingting Meng, Wenzhe Zhang, Wenzhe Zhang, Wenzhe Zhang, Wenzhe Zhang, Wenzhe Zhang, Rongrong Zhang, Rongrong Zhang, Rongrong Zhang, Rongrong Zhang, Rongrong Zhang, Jie Li, Jie Li, Jie Li, Jie Li, Jie Li, Yuan Gao, Yuan Gao, Yuan Gao, Yuan Gao, Yuan Gao, Yingying Qin, Yingying Qin, Yingying Qin, Yingying Qin, Yingying Qin, Xue Jiao, Xue Jiao, Xue Jiao, Xue Jiao, Xue Jiao, Xue Jiao   +35 more
doaj   +1 more source

Functional study on new FOXL2 mutations found in Chinese patients with blepharophimosis, ptosis, epicanthus inversus syndrome

BMC Medical Genetics, 2018
Background Blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) is a rare inheritable disease that mainly affects eyelid development associated with (type I) or without (type II) ovarian dysfunction, resulting in premature ovarian failure (POF).
Lu Zhou, Jiaqi Wang, Tailing Wang
doaj   +1 more source

The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells

eLife, 2014
FOXL2 is a lineage determining transcription factor in the ovary, but its direct targets and modes of action are not fully characterized. In this study, we explore the targets of FOXL2 and five nuclear receptors in murine primary follicular cells.
Adrien Georges, David L'Hôte, Anne Laure Todeschini, Aurélie Auguste, Bérangère Legois, Alain Zider, Reiner A Veitia   +6 more
doaj   +1 more source

Expression and localization of forkhead transcriptional factor 2 (Foxl2) in the gonads of protogynous wrasse, Halichoeres trimaculatus

Biology of Sex Differences, 2010
Background Three-spot wrasse, Halichoeres trimaculatus, is a marine protogynous hermaphrodite fish. Individuals mature either as initial phase (IP) males or females. Appropriate social cues induce the sex change from IP female to terminal phase (TP) male.
Kobayashi Yasuhisa, Horiguchi Ryo, Nozu Ryo, Nakamura Masaru   +3 more
doaj   +1 more source

expression might be a novel prognostic biomarker in patients with laryngeal squamous cell carcinoma

Journal of International Medical Research, 2020
Objectives This study aimed to explore the expression profile of the Forkhead box protein L2 gene ( FOXL2 ) and to determine its prognostic value and associated epigenetic and genetic alterations in patients with laryngeal squamous cell carcinoma (LSCC).
Jun Ge, Li Jiang, Yuke Tian, Min Zheng, Meiling Huang, Juan Li   +5 more
doaj   +1 more source

Functional Studies of Novel FOXL2 Variants in Chinese Families With Blepharophimosis–Ptosis–Epicanthus Inversus Syndrome

Frontiers in Genetics, 2021
The blepharophimosis–ptosis–epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease mainly caused by FOXL2 variants. This genetic disorder is usually characterized by eyelid malformation and ovarian dysfunction.
Fang Li, Fang Li, Huifang Chen, Huifang Chen, Yefei Wang, Yefei Wang, Jie Yang, Jie Yang, Yixiong Zhou, Yixiong Zhou, Xin Song, Xin Song, Jiayan Fan, Jiayan Fan   +13 more
doaj   +1 more source