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Growth hormone deficiency in the adult
Pituitary, 2006Growth hormone deficiency (GHD) in adults may be of either adult or childhood onset and may occur as isolated GHD or as multiple hormone deficiencies. Adult-onset GHD (AoGHD) usually results from damage to the pituitary gland or hypothalamus. GH is frequently undetectable in normal subjects and thus GHD cannot be distinguished from the normal state ...
DOGA M +4 more
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Adult Growth Hormone Deficiency
Hormone Research, 2008Several reports have focused on the clinical features of the untreated GH-deficient adult and the effect of GH therapy. The results reported are strikingly unanimous. Untreated GH-deficient adults have been shown to have increased cardiovascular mortality, reduced exercise capacity, reduced muscle strength, subnormal glomerular filtration rate and ...
J O, Jørgensen +7 more
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Growth hormone therapy for adult growth hormone deficiency
Trends in Endocrinology & Metabolism, 1996GH deficiency in adult life is associated with a number of adverse biological changes including osteopenia, reduced exercise capacity, altered body composition, deleterious alterations in the lipid profile and insulin status, and reduced quality of life. Potentially, most of these changes can be reversed by GH replacement therapy.
S M, Shalet, A, Rahim, A A, Toogood
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Growth Hormone Deficiency in Adults: A Review
The American Journal of the Medical Sciences, 1996For more than 35 years, growth hormone (GH) has been used to promote linear growth in GH-deficient children. Previously, GH replacement in adults was limited to the supply of human pituitary-derived GH. In addition, until recently, GH replacement was not deemed clinically indicated.
T R, Meling, E S, Nylen
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Defining growth hormone deficiency in adults
Metabolism, 1995The absence of a distinct clinical syndrome calls for a strategy to reliably identify patients with hyposomatotropism. However, there is no consensus as to the most appropriate method of defining growth hormone (GH) deficiency in adults. Since GH secretion falls with senescence and is also reduced by obesity, both of these factors must be controlled ...
K K, Ho, D M, Hoffman
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Diagnosis of growth-hormone deficiency in adults
The Lancet, 1994There is no consensus as to the most appropriate method of diagnosing growth-hormone (GH) deficiency in adults. We have evaluated the relative diagnostic merits of measuring peak GH response to insulin-induced hypoglycaemia (insulin tolerance test), mean 24 h GH concentration derived from 20 min sampling, serum insulin-like growth factor I (IGF-I ...
D M, Hoffman +3 more
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Diagnosis of Growth Hormone Deficiency in Adults
Hormone Research, 2008The potential effects of growth hormone (GH) deficiency in adults and the importance of GH secretion in adult life have only been recognized and documented recently. It has been suggested that GH-deficient adults may have premature mortality, abnormalities in body composition and bone density with impaired physical performance and psychological well ...
M, Korbonits, M, Besser
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Management of Adult Growth Hormone Deficiency
Endocrinology and Metabolism Clinics of North America, 2007The management of adults who have severe growth hormone deficiency (GHD) includes its recognition in susceptible patients, including all subjects who have any form of hypothalamic pituitary disorder. This article also focuses on the overall management of adults who have hypopituitarism and severe GHD.
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Growth Hormone Replacement Therapy for Growth Hormone-Deficient Adults
Drugs, 1995Recent research has confirmed previous clinical suspicion that adults with pituitary disease and growth hormone (GH) deficiency have impaired physical and psychological performance even in the presence of adequate adrenal, thyroid and gonadal hormone replacement therapy.
J, Powrie, A, Weissberger, P, Sönksen
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Testing Growth Hormone Deficiency in Adults
2010Growth hormone deficiency (GHD) in adults is a recognized syndrome which is defined biochemically within an appropriate clinical context. Clinically, patients investigated for GHD should include those with signs and symptoms of hypothalamic-pituitary disease, those who have received cranial irradiation or tumor treatment and those with traumatic brain ...
Gabellieri E +4 more
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