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Adult Growth Hormone Deficiency
Nihon rinsho. Japanese journal of clinical medicine, 2002Adult-onset growth hormone deficiency (GHD) is a rare disease with an exact incidence that is not currently known, but indirect estimates based on the incidence of pituitary tumors suggest an incidence of 10 people per million annually (1). Over the last decade the adverse metabolic and psychological sequelae of adult GHD have been increasingly ...
Zehra Haider, James W. Edmondson
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Growth hormone therapy for adult growth hormone deficiency
Trends in Endocrinology & Metabolism, 1996GH deficiency in adult life is associated with a number of adverse biological changes including osteopenia, reduced exercise capacity, altered body composition, deleterious alterations in the lipid profile and insulin status, and reduced quality of life. Potentially, most of these changes can be reversed by GH replacement therapy.
S M, Shalet, A, Rahim, A A, Toogood
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Growth hormone dosing variables in growth hormone-deficient adults
Growth Hormone & IGF Research, 2006The use of growth hormone (GH) replacement for GH-deficient adults is now in its 10th year of FDA-approved use in the United States; it has been used for a longer period of time in some European countries. Despite widespread experience, there is still lack of consensus regarding the best approach to GH initiation and titration in adults with growth ...
David M, Cook, Kevin C J, Yuen
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Growth Hormone Replacement Therapy for Growth Hormone-Deficient Adults
Drugs, 1995Recent research has confirmed previous clinical suspicion that adults with pituitary disease and growth hormone (GH) deficiency have impaired physical and psychological performance even in the presence of adequate adrenal, thyroid and gonadal hormone replacement therapy.
J, Powrie, A, Weissberger, P, Sönksen
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Growth hormone deficiency in the adult
Pituitary, 2006Growth hormone deficiency (GHD) in adults may be of either adult or childhood onset and may occur as isolated GHD or as multiple hormone deficiencies. Adult-onset GHD (AoGHD) usually results from damage to the pituitary gland or hypothalamus. GH is frequently undetectable in normal subjects and thus GHD cannot be distinguished from the normal state ...
DOGA M +4 more
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Growth hormone replacement for adult growth hormone deficiency
Expert Opinion on Pharmacotherapy, 2003Growth hormone deficiency (GHD) in childhood causes growth retardation, short stature and significant impairment of adult height. Growth hormone (GH) has been given successfully to these children for > 40 years but only since the introduction of recombinant DNA technology, has enough GH been available for paediatric needs and also for other indications.
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Defining growth hormone deficiency in adults
Metabolism, 1995The absence of a distinct clinical syndrome calls for a strategy to reliably identify patients with hyposomatotropism. However, there is no consensus as to the most appropriate method of defining growth hormone (GH) deficiency in adults. Since GH secretion falls with senescence and is also reduced by obesity, both of these factors must be controlled ...
K K, Ho, D M, Hoffman
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Adult Growth Hormone Deficiency
2022Abstract The best-known effect of growth hormone (GH) is stimulation of longitudinal growth in children, but GH hormone secretion continues in adulthood and exerts well-characterized metabolic effects. Growth hormone deficiency in adult hypopituitary patients (GHDA) is associated with excess morbidity and mortality from cardiovascular ...
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Body composition in growth hormone-deficient adults
The American Journal of Clinical Nutrition, 1992Body composition in a group of growth hormone (GH)-deficient adults was compared with a control group matched for age, sex, body height, body weight, and body mass index by using bioelectrical impedance and deuterium oxide-dilution methods and hydrodensitometry.
Binnerts, A. +5 more
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Long-term growth hormone treatment in growth hormone deficient adults
Acta Endocrinologica, 1991Abstract. Growth hormone treatment in GH-deficient adults has proved beneficial in recent short-term trials, but long-term results have not yet been reported. Thirteen GH-deficient adults (4 females, 9 males; mean (sem) age 26.4 (1.7) years), who had completed 4 months of GH therapy in a double-blind placebo-controlled cross-over study were followed ...
J O, Jørgensen +7 more
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