Results 101 to 110 of about 110,453 (370)

Modification of hippocampal circuitry by adult neurogenesis [PDF]

Developmental Neurobiology, 2012
AbstractThe adult hippocampus is one of the primary neural structures involved in memory formation. In addition to synapse‐specific modifications thought to encode information at the subcellular level, changes in the intrahippocampal neuro‐populational activity and dynamics at the circuit‐level may contribute substantively to the functional capacity of
Juan, Song, Kimberly M, Christian, Guo-li, Ming, Hongjun, Song   +3 more
openaire   +2 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury.

PLoS ONE, 2020
Various brain injuries lead to the activation of adult neural stem/progenitor cells in the mammalian hippocampus. Subsequent injury-induced neurogenesis appears to be essential for at least some aspects of the innate recovery in cognitive function ...
Yacine Tensaouti, Tzong-Shiue Yu, Steven G Kernie   +2 more
doaj   +1 more source

Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

EMBO Journal, 2020
Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation
T. Bedrosian, J. Houtman, J. Eguiguren, Saeed Ghassemzadeh, N. Rund, Nicole Novaresi, Lauren Hu, Sarah L. Parylak, Ahmet M. Denli, Lynne Randolph-Moore, T. Namba, F. Gage, T. Toda   +12 more
semanticscholar   +1 more source

Meditation effects within the hippocampal complex revealed by voxel-based morphometry and cytoarchitectonic probabilistic mapping. [PDF]

, 2013
Scientific studies addressing anatomical variations in meditators' brains have emerged rapidly over the last few years, where significant links are most frequently reported with respect to gray matter (GM).
Gaser, Christian, Kurth, Florian, Luders, Eileen, Narr, Katherine L, Toga, Arthur W   +4 more
core   +2 more sources

Cdk5 is essential for adult hippocampal neurogenesis [PDF]

Proceedings of the National Academy of Sciences, 2008
The molecular factors regulating adult neurogenesis must be understood to harness the therapeutic potential of neuronal stem cells. Although cyclin-dependent kinase 5 (Cdk5) plays a critical role in embryonic corticogenesis, its function in adult neurogenesis is unknown. Here, we assessed the role of Cdk5 in the generation of dentate gyrus (DG) granule
Diane C, Lagace, David R, Benavides, Janice W, Kansy, Marina, Mapelli, Paul, Greengard, James A, Bibb, Amelia J, Eisch   +6 more
openaire   +2 more sources

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Gamma radiation-induced impairment of hippocampal neurogenesis, comparison of single and fractionated dose regimens Deterioro de la neurogénesis en el hipocampo inducida por radiación gamma, comparación de los regímenes de dosis única y fraccionada [PDF]

, 2012
Radiation therapy of the brain is associated with many consequences, including cognitive disorders. Pathogenesis of radiation induced cognitive disorder is not clear, but reduction of neurogenesis in hippocampus may be an underlying reason. 24 adult male
Azami, N.S., Jahanshahi, M., Khoshbin khoshnazar, A.R.   +2 more
core  

Serotonin and motherhood: From molecules to mood [PDF]

, 2019
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain.
Li, Ming, Lonstein, Joseph S., Pawluski, Jodi L.   +2 more
core   +3 more sources

Adult Human Hippocampal Neurogenesis: Controversy and Evidence [PDF]

Trends in Molecular Medicine, 2018
The hippocampus has been described as one of the few sites in the mammalian brain capable of generating new cells continuously throughout life. Two recent studies that report contradicting findings on adult human hippocampal neurogenesis, however, reminds us of the caveats and challenges of studying this phenomenon in postmortem tissues.
Lee, Hyunah, Thuret, Sandrine
openaire   +5 more sources