Results 131 to 140 of about 110,453 (370)

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Behavioral and epileptic phenotypes in a CHD2‐related developmental delay model

Epilepsia, EarlyView.
Abstract Objective Heterozygous loss‐of‐function mutations in the CHD2 gene, encoding chromodomain helicase DNA‐binding protein 2, are associated with severe childhood onset epilepsy, global developmental delay, and autistic features. Animal models that accurately recapitulate human phenotypes are crucial for understanding rare neurodevelopmental ...
Anat Mavashov, Shaked Turk, Yael Sarusi, Marina Brusel, Rotem Ben Tov Perry, Shir Quinn, Yael Almog, Karni Vilian, Mor Yam, Igor Ulitsky, Moran Rubinstein   +10 more
wiley   +1 more source

Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains

Neural Plasticity, 2017
The genetic background of mice has various influences on the efficacy of physical exercise, as well as adult neurogenesis in the hippocampus. In this study, we investigated the basal level of hippocampal neurogenesis, as well as the effects of treadmill ...
Jong Whi Kim, Sung Min Nam, Dae Young Yoo, Hyo Young Jung, Il Yong Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoon   +7 more
doaj   +1 more source

Network structure determines patterns of network reorganization during adult neurogenesis [PDF]

, 2009
New cells are generated throughout life and integrate into the hippocampus via the process of adult neurogenesis. Epileptogenic brain injury induces many structural changes in the hippocampus, including the death of interneurons and altered connectivity ...
Ben-Jacob, Eshel, Parent, Jack M., Sander, Leonard M., Schneider-Mizell, Casey M., Zochowski, Michal   +4 more
core  

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. [PDF]

, 2018
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease.
A Fahrner, AD Workman, Antonio J. Gutierrez, Arantxa Cebrian-Silla, Arnold R. Kriegstein, Arturo Alvarez-Buylla, AS Hill, B Seri, B Steiner, C Wang, CV Dennis, Dashi Qi, David James, DR Kornack, DR Kornack, E Gould, E Gould, Edward F. Chang, Eric J. Huang, G Kempermann, Gary W. Mathern, GW Mathern, H Suh, H van Praag, H van Praag, HJ Kang, J Altman, J Altman, JE Malberg, JJ Breunig, Jose Manuel Garcia-Verdugo, Julia Chang, Kadellyn Sandoval, Kevin W. Kelley, KJ Mathews, KL Spalding, Kurtis I. Auguste, M Komitova, M Venere, Mercedes F. Paredes, MF Eckenhoff, Michael C. Oldham, N Patzke, N Sanai, P Yang, PS Eriksson, R Knoth, S Lugert, Shawn F. Sorrells, Simone Mayer, T Sugiyama, TE Bakken, Y Zhang, Zhengang Yang   +53 more
core   +1 more source

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source

Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome [PDF]

, 2020
Li Zhang, Genay Pilarowski, Emilio Merlo Pich, Atsushi Nakatani, John Dunlop, Rina Baba, Satoru Matsuda, Masaki Daini, Yasushi Hattori, Shigemitsu Matsumoto, Mitsuhiro Ito, Haruhide Kimura, Hans T. Björnsson   +12 more
openalex   +1 more source

Negr1 controls adult hippocampal neurogenesis and affective behaviors

Molecular Psychiatry, 2019
Recent genome-wide association studies on major depressive disorder have implicated neuronal growth regulator 1 (Negr1), a GPI-anchored cell adhesion molecule in the immunoglobulin LON family.
K. Noh, Hyunkyoung Lee, Tae-Yong Choi, Yeonhee Joo, Soo-Jeong Kim, Hyejin Kim, Jin Young Kim, J. Jahng, Soojin Lee, Se-Young Choi, S. J. Lee   +10 more
semanticscholar   +1 more source

Effect of filgrastim (Recombinant human granulocyte colony stimulating factor) on spatial memory in aged rats [PDF]

, 2015
Background: Apart from functioning as a multimodal hematopoietic growth factor, granulocyte colony-stimulating factor (G-CSF) causes intense consequences on the brain.
Mehrazin, E., Sepehri, H.
core   +1 more source