Results 51 to 60 of about 502,689 (258)

The potential of statistical matching for the analysis of wider benefits of learning in later life

open access: yesEuropean Journal for Research on the Education and Learning of Adults, 2019
It is challenging to investigate wider benefits of adult learning, especially in later life, due to limited data on educational activities and non-monetary returns in large, longitudinal surveys.
Madlain Hoffmann   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Can digital data provide an additional data basis for educational reporting? The potential of search portals for continuing education programmes

open access: yesZeitschrift für Weiterbildungsforschung - Report
Digitisation has increasingly become a feature of education. Educational policy, too, has increasingly focused on digital processes and structures. Digital data opens up opportunities to improve the governance of continuing education given the inadequacy
E. Reichart   +3 more
doaj   +1 more source

CREATIVE FATHERHOOD BEHIND BARS: THE READ TO YOUR CHILD PROGRAM

open access: yesRevista Temas em Educação, 2020
More than one-half of incarcerated people in the USA are parents of minor children. Family literacy and read-aloud programs not only provide these parents with ways to connect and communicate with their children, but also encourage children’s ...
Tabitha Stickel   +2 more
doaj   +1 more source

Adult education: learning to do, or learning to be?

open access: yes
Many theories and justifications exist for Adult Education as a discipline, possibly as a reaction to the historic, and philosophical, belief that there can be no such thing as education for adults (see Arendt, 1961 or Rein, 1893) Our observations are that these theories focus on education as a tool for agency, democratic participation, and survival in
Robertson, Nicola, Prajapati, Vijayita
openaire   +2 more sources

Adult Learning

open access: yesJournal of Extension, 1984
Adult Learning: Research and Practice. Huey B. Long. New York: Cambridge Co., 1983. 367pp. $19.95.
openaire   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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