Results 111 to 120 of about 152,418 (295)

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. [PDF]

, 2014
While the hippocampus has been classically studied for its role in learning and memory, there is significant support for a role of the HPC in regulating emotional behavior.
Jimenez, Jessica C, Kheirbek, Mazen A, Tannenholz, Lindsay   +2 more
core   +2 more sources

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Astrocytes’ Contribution to Adult Neurogenesis in Physiology and Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2018
Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there is a growing body of evidence showing that, in the hippocampus, this process contributes to mechanisms of memory as well as depression.
Frédéric Cassé, Kevin Richetin, Nicolas Toni   +2 more
doaj   +1 more source

Rescue of Adult Neurogenesis in Down Syndrome Mouse Model [PDF]

, 2014
poster abstractDown Syndrome (DS) is a disease caused by the complete or partial trisomy of human chromosome 21, which can cause abnormal development, structure, and function of neural networks in the brain.
East, Josh
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source