Results 81 to 90 of about 3,058,602 (268)

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Current perspectives on the role of oxytocin receptor (OXTR) gene variants in panic disorder: associations with disease liability and separation anxiety

Archives of Medical Science
Introduction Oxytocin receptor (OXTR) gene variations are associated with empathy, trust, emotional stability, stress reactivity, social bonding and attachment behaviors.
Zeynep Yegin, Gokhan Sarisoy, Ahmet Uzun, Yasin Altinisik   +3 more
doaj   +1 more source

قلق الانفصال وعلاقته بأساليب التعلق لدى طلاب المنح الوافدون في الجامعات السعودية: دراسة في ضوء بعض المتغيرات الديموغرافية Separation Anxiety and Its Relationship with Attachment Styles among International Scholarship Students in Saudi Universities: A Study in Light of Some Demographic Variables [PDF]

Maǧallaẗ Al-I'ršād Al-Nafsī
الملخص هدفت الدراسة إلى الكشف عن مستوى قلق الانفصال لدى طلاب المنح الوافدين بجامعة الإمام محمد بن سعود الإسلامية، وتحديد العلاقة بين أساليب التعلق وقلق الانفصال، والكشف عن الفروق وفق مدة الإقامة في الجامعة.
سامى بن سعيد بن عبد الله الزهرانى
doaj   +1 more source

THE RELATIONSHIP BETWEEN ADULT SEPARATION ANXIETY AND SELF-ESTEEM IN PATIENTS DIAGNOSED WITH GENERALISED ANXIETY DISORDER

Objective: This study aimed to examine the relationship between self-esteem and both childhood and adult separation anxiety in individuals diagnosed with anxiety disorders, and to evaluate the predictive role of self-esteem on adult separation anxiety ...
Fatma Kartal, Merve Karataş, Hatice Polat, Hayriye Mihrimah Öztürk, Koray Yarız   +4 more
core   +1 more source

Adult Separation Anxiety Disorder: The Human-Animal Bond [PDF]

, 2019
This item is only available electronically.Separation anxiety has traditionally been considered a psychological disorder with an onset in childhood or adolescence.
Dowsett, Elisha
core  

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E is an element of 4 status and cerebrospinal fluid amyloid-beta 42 levels [PDF]

, 2014
Introduction: Emerging evidence suggests that decreased adult hippocampal neurogenesis represents an early critical event in the course of Alzheimer's disease (AD).
Annas, Peter, Hans Basun, Basun, Hans, Keith A Wesnes, Edgar, Chris, Peter Annas, Wesnes, KA, Basun, H, Kaj Blennow, Blennow, K, Wesnes, Keith, Blennow, Kaj, Chris Edgar, Edgar, C, Annas, P,   +14 more
core   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Separation Anxiety and Depressive Symptoms in Latin-American University Students: the role of Interpersonal Problem Areas

Mediterranean Journal of Clinical Psychology
Background: Research on depressive symptoms and interpersonal issues in foreign university students (FS) remains limited. This study assessed interpersonal problem areas, depressive symptoms, and adult separation anxiety (ASA) in Latin-American FS ...
Mario Miniati, Graziella Orrù, Giorgia Papini, Stephanie Vergara-Aizprua, Rebecca Ciacchini, Laura Palagini, Ciro Conversano, Angelo Gemignani   +7 more
doaj   +1 more source