Results 131 to 140 of about 1,403,852 (427)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Barriers and Solutions to Advance Care Planning among Homeless-Experienced Older Adults. [PDF]

, 2020
Background/Objectives: Older homeless-experienced adults have low rates of advance care planning (ACP) engagement despite high rates of morbidity and mortality.
Arellano Cuervo, Isabel, Bainto, Dustin, Kaplan, Lauren M, Kushel, Margot, Olsen, Pamela, Sudore, Rebecca L   +5 more
core   +2 more sources

Barriers to advance care planning: a qualitative study of seriously ill Chinese patients and their families

BMC Palliative Care, 2020
Background Advance care planning (ACP) facilitates identification and documentation of patients’ treatment preferences. Its goal aligns with that of palliative care – optimizing quality of life of seriously ill patients.
Johnny T. K. Cheung, D. Au, A. Ip, J. Chan, K. Ng, L. Cheung, J. Yuen, E. Hui, Jenny Lee, R. Lo, J. Woo   +10 more
semanticscholar   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source

Development and validation of a questionnaire to detect behavior change in multiple advance care planning behaviors. [PDF]

PLoS ONE, 2013
Advance directives have traditionally been considered the gold standard for advance care planning. However, recent evidence suggests that advance care planning involves a series of multiple discrete behaviors for which people are in varying stages of ...
Rebecca L Sudore, Anita L Stewart, Sara J Knight, Ryan D McMahan, Mariko Feuz, Yinghui Miao, Deborah E Barnes   +6 more
doaj   +1 more source

Mathematical model optimized for prediction and health care planning for COVID-19 [PDF]

arXiv, 2020
Objective. The COVID-19 pandemic has threatened to collapse hospital and ICU services, and it has affected the care programs for non-COVID patients. The objective was to develop a mathematical model designed to optimize predictions related to the need for hospitalization and ICU admission by COVID-19 patients. Design. Prospective study.
arxiv  

Um Estudo sobre Atividades Participativas para Soluções IoT para o Home care de Pessoas Idosas [PDF]

arXiv, 2021
Population aging in Brazil and in the world occurs at the same time of advances and evolutions in technology. Thus, opportunities for new solutions arise for the elderly, such as innovations in Home Care. With the Internet of Things, it is possible to improve the elderly autonomy, safety and quality of life.
arxiv  

Does facilitated Advance Care Planning reduce the costs of care near the end of life? Systematic review and ethical considerations [PDF]

, 2015
Background: While there is increasing evidence that Advance Care Planning has the potential to strengthen patient autonomy and improve quality of care near the end of life, it remains unclear whether it could also reduce net costs of care.
Klingler, Corinna, Marckmann, Georg, Schmitten, Jürgen in der   +2 more
core   +1 more source

Advance and future care planning

BMJ
Patients, relatives, and healthcare professionals recognise the value of pre-emptive consideration and documentation of what treatments might be wanted and beneficial in an emergency. In the past, the most common advance planning documentation was a “do not attempt cardiopulmonary resuscitation” (DNACPR) notice.
Hyson, Lara, Fritz, Zoë
openaire   +2 more sources

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source