Results 151 to 160 of about 492 (217)
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
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ADVANCING AN ADVANCE DIRECTIVE DEBATE
Bioethics, 2008ABSTRACTA challenge has recently been levelled against the legal and/or moral legitimacy of some advance directives. It has been argued that in certain cases an advance directive carries no weight in a decision on whether to withhold treatment, since the individual in the debilitating state is not the same person as the person who created the advance ...
exaly +3 more sources
BMJ, 2011
“Fight, fight, fight!” The children thronged around the two kids wrestling each other. It was a school spectacle, before children spent their lives on Facebook. It was generally the same people—“trouble makers”—crazed guys that you never made eye contact with.
openaire +2 more sources
“Fight, fight, fight!” The children thronged around the two kids wrestling each other. It was a school spectacle, before children spent their lives on Facebook. It was generally the same people—“trouble makers”—crazed guys that you never made eye contact with.
openaire +2 more sources
Annual Review of Medicine, 2008
Most patients want some control over their medical care, including—or even especially—when they are too sick to participate in decisions. Clinicians who have to make decisions for patients who are unable to participate often would appreciate guidance from patients’ wishes. Advance care planning responds to these needs.
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Most patients want some control over their medical care, including—or even especially—when they are too sick to participate in decisions. Clinicians who have to make decisions for patients who are unable to participate often would appreciate guidance from patients’ wishes. Advance care planning responds to these needs.
openaire +2 more sources
Nursing Older People, 2010
Advance care directives are statements either made orally or in writing by mentally competent adults stating how they wish to be treated should they, at some stage in the future, lose mental capacity. In practice, however, advance care planning is rarely used; end-of-life decisions are made by physicians or family.
openaire +2 more sources
Advance care directives are statements either made orally or in writing by mentally competent adults stating how they wish to be treated should they, at some stage in the future, lose mental capacity. In practice, however, advance care planning is rarely used; end-of-life decisions are made by physicians or family.
openaire +2 more sources