Results 141 to 150 of about 849,640 (304)

Reply to 'Who Should Make Medical Decisions When a Patient Lacks an Advance Directive?' [PDF]

Neurohospitalist, 2022
Ioannou P.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Advance directive promotion in the community setting [PDF]

Problem: An advance directive is a recognized legal document that expresses a person\u27s own wishes and values which will guide medical decision making in the event of serious illness or incapacity.
Dugan, Erin
core  

An Educational Intervention to Increase Advance Directive Completion [PDF]

, 2016
In the United States, it is common for patients to receive prolonged, aggressive medical care at the end of life (Levi & Green, 2010). This level of medical care may or may not be in alignment with patients’ wishes.
Harlow, Kimberly
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Experiences of Older Adults with Frailty Not Completing an Advance Directive: A Qualitative Study of ACP Conversations. [PDF]

Int J Environ Res Public Health, 2022
Wan Z, Chan HYL, Chiu PKC, Lo RSK, Cheng HL, Leung DYP.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Association of Chinese Ethnicity and Language Preference with Advance Directive Completion Among Older Patients in an Integrated Health System. [PDF]

J Gen Intern Med, 2023
Oh DHW, Conell C, Lyon L, Ramalingam ND, Virk L, Gonzalez R.   +5 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Advance Directive Completion Among Black Adults Within a Community-Based Integrated Health Care System. [PDF]

Perm J, 2022
Himmelstein J, Lyon L, Gong C, Conell C, Ramalingam N, Chavez K, Virk L, Gonzalez R.   +7 more
europepmc   +1 more source