Results 121 to 130 of about 849,640 (304)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Commentary: Can an effective end‐of‐life intervention for advanced dementia be viewed as moral?
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease MonitoringWe comment on Dr. Terman's considerations on the moral justification of ceasing assisted feeding and hydration for people with advanced dementia. The core idea of his paper is that an advance directive can solve future dilemmas regarding assisted feeding.
Trijntje M. Scheeres‐Feitsma +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Interventions to Promote the Use of Advance Directives: An Overview of Systematic Reviews
, 2010 To identify, appraise and synthesise the results of systematic reviews of the literature (SRLs) that examines the effectiveness of interventions to increase advance directive (AD) completion ...
Tamayo-Velázquez, Maria-Isabel +6 more
core +1 more source
BMC Palliative CareBackground People living with severe mental illness (SMI) face significant health inequalities, including in palliative care. Advance Care Planning (ACP) is widely recommended by palliative care experts and could reduce inequalities.
Rea Kaur Gill +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Hospital Policy on Advance Directives: Do Institutions Ask Patients About Living Wills?
, 1989 Hospitals throughout the United States were surveyed in 1988 to determine their policies on advance directives, including living wills and durable power of attorney documents.
McCrary, S. Van, Botkin, Jeffrey R.
core +1 more source
Perspectives of psychiatrists on Mental Health Care Act, 2017: An in-depth pilot survey
Industrial Psychiatry JournalBackground: The Mental Health Care Act, 2017 (MHCA, 17) was passed through both houses of the parliament. The Indian Psychiatric Society through its Patient’s Rights Task Force committee has been deliberating various rounds of discussion at levels of ...
Astha, Shruti Srivastava, Indira Sharma
doaj +1 more source