Results 131 to 140 of about 18,025 (260)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Predictors of Advance Directive Changes in Ontario Nursing Home Residents: A Case-Control Study. [PDF]

J Am Geriatr Soc
Wong HJ, Seow H, Gayowsky A, Wu RC, Lim H, Sutradhar R.   +5 more
europepmc   +1 more source

Prevalence and predictors of advance directive among terminally ill patients in Taiwan before enactment of Patient Right to Autonomy Act: a nationwide population-based study. [PDF]

BMC Palliat Care, 2022
Chang HY, Takemura N, Chau PH, Lin CC.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mental Capacity and Advance Directive of Persons with Mental Illness: A Descriptive Cross-sectional Study from India. [PDF]

Indian J Psychol Med
Bipeta R, Rathi MM, Molanguri U.
europepmc   +1 more source

Understanding the needs of people aging with type 1 diabetes: a user-focused research study with prototype diabetes advance directive and setting the stage for future research. [PDF]

J Diabetes Metab Disord, 2022
Lewis DM, Milo J, Espares J, Lin J, Li J, Tang D, Rataj H, Aronoff-Spencer E.   +7 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Willingness to develop an advance directive: perspectives of older persons at a national referral hospital in Uganda. [PDF]

BMC Med Ethics
Alupo C, Mwaka ES, Kwagala B, Ochieng J.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Enhancing Advance Directive Completion Among Older Adults in the Geriatrics Clinic in Indiana, USA: A Quality Improvement Initiative. [PDF]

Healthcare (Basel)
Guillen AGP, Recarte TA, Castillo MP, Ramirez MEZ, Mártir JFS.   +4 more
europepmc   +1 more source