Results 101 to 110 of about 1,191,211 (370)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Prevalence and Contents of Advance Directives of Patients with ESRD Receiving Dialysis.

open access: yesAmerican Society of Nephrology. Clinical Journal, 2016
BACKGROUND AND OBJECTIVES ESRD requiring dialysis is associated with increased morbidity and mortality rates, including increased rates of cognitive impairment, compared with the general population. About one quarter of patients receiving dialysis choose
M. Feely   +3 more
semanticscholar   +1 more source

Patient attitudes towards advance directives. [PDF]

open access: yes, 2002
Purpose: To explore hospitalized patients’ attitudes toward advance directives, their reasons for completing or not completing advance directive forms, and demographic differences between patients who did and did not complete advance directive forms ...
Brown, Hazel N.   +1 more
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Medisinsk behandling og bindende forhåndsønsker- Noe for Norge? : En oversikt og diskusjon om verdien av forhåndsønsker og pasientens rett til å oppnevne stedfortredende beslutningstaker [PDF]

open access: yes, 2009
A patient’s opportunity to affect and participate in decision-making with regard to their own medical care is considered important. Most patients want some control over their medical care, including or even especially, when they are too sick to ...
Løitegård, Kjetil
core  

Legal dilemmas of maternal brain death: The case of Marlise Muñoz [PDF]

open access: yesGlasnik Advokatske komore Vojvodine, 2020
The subject of this article is a case that occurred in Texas in 2013, which has caused great debate between medical and legal professionals, and has stirred public concern.
Drljača Jagoda V.
doaj  

Adherence to advance directives: GMC's advance directive is commendable

open access: yesBMJ, 2003
Editor—Thompson et al's article on adherence to advance directives is a telling exploration of an increasingly relevant issue.1 The vignette they constructed was comprehensive and robust, leaving no reasonable person in any doubt about the nature and severity of conditions for which the patient would refuse intervention.
openaire   +3 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Prevalence of advance care directives in the community: a telephone survey of three Australian States

open access: yesInternal medicine journal (Print), 2019
The community prevalence of advance care directives (ACD) is low despite known benefits of advance care planning for patients, families and health professionals.
B. White   +9 more
semanticscholar   +1 more source

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