Results 61 to 70 of about 181,108 (308)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Nurses’ Opinions on the Advance Directives for Care of Terminal Stage in Songklanagarind Hospital.

Journal of Health Science and Medical Research (JHSMR), 2013
Objective: 1) To study nurses’ opinions on advance directives. 2) To compare nurses’ opinions on advance directives for care of terminal stage among nurses with different proficiency levels.
Uaiporn Pattrapakdikul, Sirin Sastranuruk   +1 more
doaj  

Content analysis of Advance Directives completed by patients with advanced cancer as part of an Advance Care Planning intervention : insights gained from the ACTION trial [PDF]

, 2020
Purpose Writing an Advance Directive (AD) is often seen as a part of Advance Care Planning (ACP). ADs may include specific preferences regarding future care and treatment and information that provides a context for healthcare professionals and relatives ...
Caswell, G, Deliens, Luc, Ingravallo, F, Jabbarian, LJ, Johnsen, AT, Kars, MC, Korfage, IJ, Mimić, A, Møller Arnfeldt, C, Preston, NJ, van Delden, JJM, Zwakman, Marieke   +11 more
core   +4 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Advance Directives as Support of Autonomy for Persons with Dementia A Pilot Study among Persons with Dementia and Their Informal Caregivers

Dementia and Geriatric Cognitive Disorders Extra, 2017
Background: Advance directives could be an important instrument to support a person’s will once he/she is not able to consent anymore – if composed competently. A survey was conducted to identify the level of knowledge concerning possibilities and limits
Martina Schmidhuber, Sandra Haeupler, Velislava Marinova-Schmidt, Andreas Frewer, Peter L. Kolominsky-Rabas   +4 more
doaj   +1 more source

A study on the relationship of death anxiety and the completion of advance directives for oncology social workers [PDF]

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Peck, Marlys R., 1964-
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Prevalence, clinical impact and associated patient-centred outcomes of advance directives in Swiss intensive care units: Results from the retrospective ADVISE Study

Swiss Medical Weekly
STUDY AIMS: Data on the usefulness of advance directives for end-of-life decision-making in intensive care units (ICUs) are scarce. The primary aim of the present study was to investigate the prevalence of advance directives in patients of two Swiss ...
Sira Maria Baumann, Dominik Vock, Paulina S. C. Kliem, Simon A. Amacher, Yasmin Erne, Pascale Grzonka, Sebastian Berger, Martin Lohri, Sabina Hunziker, Caroline E. Gebhard, Mathias Nebiker, Luca Cioccari, Raoul Sutter   +12 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Novel approach to advance directive training: Hospice and palliative care fellow led workshop feasible and effective in increasing confidence in end of life conversations.

PLoS ONE
Despite the benefits of Advance directives, approximately only 1 in 3 U.S adults have documented advance directives. In medical school and residency, learners are often not taught or given very brief information on conducting end-of-life planning ...
Chelsea Chang, Jose Cano, Juan Lopez-Alvarenga, Josenny Rodriguez-Paez, Sonya Montes, Rosa White, Meghana Rao   +6 more
doaj   +1 more source