Results 91 to 100 of about 49,140 (359)

NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification [PDF]

, 2005
The non-enzymatic reaction between reducing sugars and long-lived proteins in vivo results in the formation of glycation and advanced glycation end products, which alter the properties of proteins including charge, helicity, and their tendency to ...
Howard, Mark J., Smales, Christopher Mark   +1 more
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Autophagy Plays a Protective Role in Advanced Glycation End Product-Induced Apoptosis in Cardiomyocytes

Cellular Physiology and Biochemistry, 2015
Background/Aims: To investigate the effect of advanced glycation endproduct-induced autophagy in rat cardiomyocytes and to identify the role of autophagy in advanced glycation end product-induced cell apoptosis. Methods: After cultured rat cardiomyocytes
Pengfei Hu, Hui Zhou, Ming Lu, Liping Dou, Gang Bo, Jiale Wu, Shuwei Huang   +6 more
doaj   +1 more source

DYSREGULATION OF GASTROINTESTINAL RAGE (RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS) EXPRESSION IN A SPONTANEOUS ANIMAL MODEL OF INFLAMMATORY BOWEL DISEASE [PDF]

, 2021
Angela Isabel Cabrera-García, Martina Protschka, Stefanie Kather, Franziska Dengler, Gottfried Alber, Uwe Müller, Jöerg M. Steiner, Romy M. Heilmann   +7 more
openalex   +1 more source

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, EarlyView.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs

Disease Models & Mechanisms, 2018
Back pain is a leading cause of disability and is strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge.
Divya Krishnamoorthy, Robert C. Hoy, Devorah M. Natelson, Olivia M. Torre, Damien M. Laudier, James C. Iatridis, Svenja Illien-Jünger   +6 more
doaj   +1 more source

Deterioration of willow seeds during storage [PDF]

, 2018
Willow (Salix spp.) seeds are able to tolerate desiccation, but differ from typical orthodox seeds in that they lose viability in a few days at room temperature, and in that the chloroplasts in embryo tissues do not dedifferentiate during maturation ...
Burrieza, Hernán Pablo, Correa, María Daniela, Lopez Fernandez, Maria Paula, Maldonado, Sara Beatriz, Moyano, Laura, Vasile, Franco Emanuel   +5 more
core   +2 more sources

Advanced Glycation End Products, Soluble Receptor for Advanced Glycation End Products, and Risk of Colorectal Cancer [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2011
Abstract Background: Advanced glycation end products (AGE) accumulate in human tissue proteins during aging, particularly under hyperglycemia conditions. AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE–ligand engagement ...
Li, Jiao, Philip R, Taylor, Stephanie J, Weinstein, Barry I, Graubard, Jarmo, Virtamo, Demetrius, Albanes, Rachael Z, Stolzenberg-Solomon   +6 more
openaire   +2 more sources

Targeting the Hyperglycemic Pre‐Metastatic Niche to Prevent Breast Cancer Bone Metastasis: Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
Abstract The recent pioneering study by Ye et al. (Adv Sci. 2025;12(37):e0504924) provides compelling evidence that systemic hyperglycemia orchestrates a pre‐metastatic niche (PMN) in bone, promoting breast cancer metastasis and identifying Receptor for Advanced Glycation End‐products (RAGE) inhibition as a viable therapeutic strategy.
DuJiang Yang, Jiexiang Yang, GuoYou Wang
wiley   +1 more source

Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues [PDF]

, 2020
The autofluorescence (AF) characteristics of endogenous fluorophores allow the label-free assessment and visualization of cells and tissues of the human body.
Aigner, Felix, Pratschke, Johann, Schumann, Teresa, Stockmann, Martin, Tacke, Frank, Theil, Donna, Wizenty, Jonas, Wuensch, Tilo   +7 more
core   +1 more source