Results 281 to 290 of about 49,140 (359)

Statins decreases vascular epithelial growth factor (VEGF) expression in experimental age-related macular degradation (AMD) model by down-regulation of receptor for advanced glycation end-products (RAGE)

, 2017
Hiroki Tsujinaka, Asako Itaya‐Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto‐Tsuchida, Mai Makino, Ryogo Shobatake, Naonori Masuda, Hiromasa Hirai, Shin Takasawa, Nahoko Ogata   +9 more
openalex   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

Machine Learning Integration Framework Constructs a Lactylation‐Associated Gene Signature to Improve Prognosis in Bladder Cancer

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Bladder cancer remains a significant challenge in oncology owing to its high recurrence rates and limited treatment options, particularly in cases of resistance to standard therapies. Aims Our study aimed to pinpoint a lactylation‐associated gene signature capable of predicting prognosis and providing important theoretical support ...
Jingsong Wang, Qianxue Lu, Panpan Jiao, Jun Jian, Qingyuan Zheng, Zhiyuan Chen, Xiuheng Liu, Shanshan Wan, Lei Wang   +8 more
wiley   +1 more source

Development of New Benzo[b]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists

ChemMedChem, Volume 21, Issue 1, January 2026.
A streamlined Ullmann‐Goldberg strategy enabled the synthesis of benzo[b]thiophene‐2‐carboxamides, promising ligands of the pro‐inflammatory RAGE receptor involved in inflammaging and age‐related diseases. LC‐MS, NMR, X‐ray and DFT studies elucidated the copper‐catalyzed mechanism. The lead compound, 3t’, shows inhibitory activity on the sRAGE/AGE2‐BSA
Lisa Bonin, Matthieu Hedouin, Christophe Furman, Ophélie Not, Steve Lancel, Mona Bensalah, Gael Coadou, Eric Boulanger, Sergiu Shova, Hassan Oulyadi, Alina Ghinet   +10 more
wiley   +1 more source

Resveratrol attenuates advanced glycation end product-induced senescence and inflammation in human gingival fibroblasts. [PDF]

J Dent Sci
Huang CY, Chen SH, Lin T, Liao YW, Chang YC, Chen CC, Yu CC, Chen CJ.   +7 more
europepmc   +1 more source

Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine

ChemMedChem, Volume 21, Issue 1, January 2026.
A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda, Dolores Aguilar‐Cázares, Angélica Flores–Flores, Miguel Ángel Santos‐Contreras, José S. López‐González, Rodrigo Aguayo‐Ortiz, Rogélio Hernández‐Pando, Francisco Hernández‐Luis   +7 more
wiley   +1 more source

Clearance Kinetics and Matrix Binding Partners of the Receptor for Advanced Glycation End Products

, 2014
Pavle S. Milutinovic, Judson M. Englert, Lauren T. Crum, N. Scott Mason, Lasse Ramsgaard, Jan J. Enghild, Louis J. Sparvero, Michael T. Lotze, Tim D. Oury   +8 more
openalex   +2 more sources

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

ChemMedChem, Volume 21, Issue 1, January 2026.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés, Silvia Micháliková, Petronela Rezbáriková, L. Michel Espinoza‐Fonseca, Jana Viskupičová   +4 more
wiley   +1 more source

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Weidong Zhang, Shasha Li, Yajun Cui, Yuhui Lun, Hongrui Liu, Minqi Li   +5 more
wiley   +1 more source