Results 91 to 100 of about 3,175,008 (304)

Northwest Advanced Renewables Alliance, 3rd Cumulative Report, April 2014-March 2015 [PDF]

, 2015
This report covers activities by the Northwest Advanced Renewables Alliance (NARA) from April 2014-March 2015, covering its organizational structure, key partnerships, and strategic goals.
Northwest Advanced Renewables Alliance
core  

SARS-CoV-2 RBD Scaffolded by AP205 or TIP60 Nanoparticles and Delivered as mRNA Elicits Robust Neutralizing Antibody Responses

Vaccines
Background/Objectives: SARS-CoV-2 vaccine candidates comprising the receptor binding domain (RBD) of the spike protein have been shown to confer protection against infection.
Johnathan D. Guest, Yi Zhang, Daniel Flores, Emily Atkins, Kuishu Ren, Yingyun Cai, Kim Rosenthal, Zimeng Wang, Kihwan Kim, Charles Chen, Richard Roque, Bei Cheng, Marianna Yanez Arteta, Liping Zhou, Jason Laliberte, Joseph R. Francica   +15 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Intraspecies comparative genomics of three strains of Orientia tsutsugamushi with different antibiotic sensitivity

Genomics Data, 2017
We recently reported the genome of Orientia tsutsugamushi (OT) strain Karp (GenBank Accession #: NZ_LYMA00000000.2, https://www.ncbi.nlm.nih.gov/nuccore/NZ_LYMA00000000.2) with >2 Mb in size through clone-based sequencing and high throughput genomic ...
Hsiao-Mei Liao, Chien-Chung Chao, Haiyan Lei, Bingjie Li, Shien Tsai, Guo-Chiuan Hung, Wei-Mei Ching, Shyh-Ching Lo   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Advanced Therapies in Elderly Patients With Inflammatory Bowel Disease: A Comparative Retrospective Cohort Study in Taiwan [PDF]

Shih-Hua Lin,1– 3 Horng-Yih Chiu,2 Chia-Jung Kuo,2– 6 Chien-Ming Chen,7 Ming-Yao Su,1– 3 Ren-Chin Wu,8 Cheng-Tang Chiu,2– 6 Chen-Wang Chang,3,9 Chen-Shuan Chung,3,10 Yu-Bin Pan,11 Puo-Hsien Le2– 6 1Division of Gastroenterology and Hepatology, Department ...
Pan YB, Le PH, Chang CW, Chiu HY, Chiu CT, Chen CM, Wu RC, Chung CS, Kuo CJ, Su MY, Lin SH   +10 more
core  

Advanced cell therapies with and without scaffolds

, 2011
Tissue engineering and regenerative medicine aim to produce tissue substitutes to restore lost functions of tissues and organs. This includes cell therapies, induction of tissue/organ regeneration by biologically active molecules, or transplantation of ...
Pinar Y. Huri, Demirbag, Birsen, Arda Buyuksungur, Huri, Pinar Y., Gamze T. Kose, Hasırcı, Vasıf Nejat, Vasif Hasirci, Birsen Demirbag, Buyuksungur, Arda, HASIRCI, VASIF NEJAT, Kose, Gamze T., Hasirci, Vasif, KÖSE, GAMZE, HURİ, PINAR   +13 more
core   +1 more source

Future Perspectives of Pulmonary Arterial Hypertension: A Review of Novel Pipeline Treatments and Indications

Drugs in R&D
Pulmonary arterial hypertension is characterized by elevated blood pressure and pathological changes in the pulmonary arterioles, leading to the development of right-heart failure and potentially fatal outcomes if left untreated.
Maria Eugenia Novara, Enrica Di Martino, Brandon Stephens, Mary Nayrouz, Patrizio Vitulo, Anna Carollo, Alessio Provenzani   +6 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source