Results 101 to 110 of about 3,175,008 (304)

Dose Escalation Patterns and Associated Costs of Advanced Therapies for Ulcerative Colitis in France and the United Kingdom: A Retrospective Database Analysis [PDF]

Tamás Treuer,1 Melissa Richards,1 Can Mert,2 Endip Dhesi,1 Lidia Silva,3 Yubo Tan,4 Sami Hoque5 1International Medical Affairs, Eli Lilly and Company, Indianapolis, IN, USA; 2Statistics, HaaPACS GmbH, Schriesheim, Germany; 3RWE, TFS HealthScience, Madrid,
Mert C, Hoque S, Richards M, Silva L, Tan Y, Dhesi E, Treuer T   +6 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Update on targeted therapies for advanced non-small cell lung cancer: nivolumab in context

, 2017
Alexander D Le,1,* Saeed K Alzghari,2,* Gary W Jean,2 Ninh M La-Beck1 1Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, 2Department of Pharmacy Practice, School of Pharmacy ...
La-Beck NM, Le AD, Alzghari SK, Jean GW
core  

Looking for alternatives risk, reflexivity and complementary Therapies [PDF]

, 2005
This thesis explores individuals' motivations for using complementary and alternative medicines (CAM). More specifically, the thesis explores the relationship between the use of CAM and wider social and cultural changes which have altered individuals ...
Brooks, Lauren
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The implications of advanced therapies regulation

Recent policy developments in the United States and Europe have created new regulatory regimes for advanced and complex treatments such as cell therapies, tissue engineering, and gene therapies that are of particular relevance for regenerative medicine ...
Sethe S
core   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The role of left atrio-ventricular coupling index and left atrial ejection fraction in predicting onset of atrial fibrillation and adverse cardiac events in hypertrophic cardiomyopathy

Cardiovascular Ultrasound
Background Several predictors of atrial fibrillation (AF) onset in patients with hypertrophic cardiomyopathy (HCM) have been proposed, however, all of them showed limited accuracy.
Parisi Francesca, La Franca Eluisa, Pistelli Lorenzo, Gentile Giovanni, Bellavia Diego, Nuzzi Vincenzo, Manca Paolo, Massimiliano Mulè, Zito Concetta, Di Bella Gianluca, Scipione Carerj, Cipriani Manlio, Francesco F. Faletra   +12 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source