Results 51 to 60 of about 552,110 (322)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A National Adverse Drug Reaction Reporting System for Malta [PDF]

, 2004
The mission of the Medicines Authority (MA) in Malta is to contribute to protection of public health through regulation of the safety, quality and efficacy of medicines for human use on the local market and to ensure that healthcare professionals and ...
Arthur, Niamh, Bonett, Michael, Vella Bonanno, Patricia   +2 more
core  

Comparison of algorithms that detect drug side effects using electronic healthcare databases [PDF]

, 2013
The electronic healthcare databases are starting to become more readily available and are thought to have excellent potential for generating adverse drug reaction signals.
A Bate, Daniele Soria, EP Puijenbroek van, HW Jin, Jack Gibson, JD Lewis, Jenna Marie Reps, Jonathan M. Garibaldi, JR Curtis, JS Brown, NL Story, RA Wilke, Richard Hubbard, SJW Evans, Uwe Aickelin, W DuMouchel, X Zhou   +16 more
core   +4 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Active surveillance of adverse drug reactions in patients with rheumatoid arthritis in a tertiary care teaching hospital [PDF]

, 2018
Background: Drugs used in the treatment of rheumatoid arthritis show significant toxicity and morbidity. The objective of the study was to evaluate the nature and incidence of adverse drug reaction in patients with rheumatoid arthritis on anti-rheumatic ...
., Vidhya, B., Meenakshi, D., Keerthi, J., Ezhil Ramya, R., Nalini   +4 more
core   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Cytomegalovirus infection initiates inflammatory bowel disease by activating a positive MyD88/NF-κB feedback loop in allogeneic skin transplantation mice

Virology Journal
Infection with the cytomegalovirus (CMV) is common. Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract. CMV infection is involved in IBD pathogenesis. The abnormal activation of myeloid differentiation
Ming-Xian Chen, Yu Chen, Rui Fu, Jie-Yi Wang, Sai-Yue Liu, Tang-Biao Shen   +5 more
doaj   +1 more source

Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh’s National Kala-azar Elimination Programme

Infectious Diseases of Poverty, 2018
Background Adverse effects of antileishmanial drugs can affect patients’ quality of life and adherence to therapy for visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL).
Md. Sakhawat Hossain, Amresh Kumar, A.F.M Akhtar Hossain, Md. Mahshin, Abhijit Sharma, Md. Akter Hossain, Varun Sharma, Rashidul Haque, A.K.M Shamsuzzaman, Shomik Maruf, Prakash Ghosh, Vivek Ahuja, Dinesh Mondal   +12 more
doaj   +1 more source

Rational Organisation of Adverse Drug Reaction Monitoring

Безопасность и риск фармакотерапии, 2022
The main pharmacoepidemiological method for assessing the efficacy and safety of ongoing pharmacotherapy involves the collection of spontaneous reports on adverse drug reactions (ADRs) associated with the use of medicines.The aim of the study was to ...
L. V. Shukil, S. G. Fominykh, V. A. Akhmedov, T. E. Perepichkina   +3 more
doaj   +1 more source

Unsupervised extraction of adverse drug reaction relationships [PDF]

, 2015
En este trabajo se presentan los resultados preliminares de una nueva técnica no supervisada para la extracción de relaciones entre medicamentos y efectos adversos.
Araujo Serna, Lourdes, Duque Fernández, Andrés, Martínez Romo, Juan   +2 more
core   +1 more source