Results 41 to 50 of about 312,960 (309)

Is There a Risk of Lymphoma Associated With Anti-tumor Necrosis Factor Drugs in Patients With Inflammatory Bowel Disease? A Systematic Review of Observational Studies

Frontiers in Pharmacology, 2019
Background: Inflammatory bowel diseases (IBDs) are generally not considered a risk factor for the development of lymphoma. When considering IBD treatments, there is good evidence supporting thiopurines (azathioprine, 6-mercaptopurine) as a risk factor ...
Sara Ferraro, Luca Leonardi, Irma Convertino, Corrado Blandizzi, Corrado Blandizzi, Marco Tuccori, Marco Tuccori   +6 more
doaj   +1 more source

Practice, knowledge, and attitude about adverse drug reactions, adverse drug reaction reporting and pharmacovigilance among undergraduates, house surgeons, and post-graduates of a tertiary care teaching hospital in Andhra Pradesh – A cross-sectional questionnaire-based study

National Journal of Physiology, Pharmacy and Pharmacology, 2023
Background: Adverse drug reactions (ADRs) are important cause of morbidity and mortality. ADR reporting will help to identify and prevent ADR. However, lack of awareness and sensitization make it a difficult task. There is under reporting of ADR.
Suresh Malla, Venugopal Rao Tanneru, Vinutha S, Lakshmana Rao N   +3 more
doaj   +1 more source

Adverse reactions to drugs

BMJ, 1998
An adverse reaction to a drug has been defined as any noxious or unintended reaction to a drug that is administered in standard doses by the proper route for the purpose of prophylaxis, diagnosis, or treatment. Some drug reactions may occur in everyone, whereas others occur only in susceptible patients.
D, Vervloet, S, Durham
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Evaluating and Optimising the Retrieval of Research Evidence for Systematic Reviews of Adverse Drug Effects and Adverse Drug Reactions [PDF]

, 2013
Systematic reviews can provide timely, reliable evidence on which to make informed decisions. In order to make balanced decisions, information is not only needed on the benefits of an intervention, but also on its adverse effects.
Golder, Su
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

“Adverse Drug Reaction Reporting” Knowledge, Attitude and Practices of Community Pharmacy Dispensers in Dar es salaam, Tanzania [PDF]

, 2011
Under reporting of adverse drug reactions (ADRs) by healthcare personnel is a common problem of many Pharmacovigilence programs. Lack of involvement of healthcare professionals such as pharmacists and other pharmaceutical dispensers has been cited as one
Shimwela, Grace Mng’ong’o
core  

Comment on: “Adverse Drug Reaction-Related Hospitalizations in Elderly Australians: A Prospective Cross-Sectional Study in Two Tasmanian Hospitals”

, 2017
We read with interest the recent study by Nair et al. [1] about adverse drug reaction (ADR)-related hospitalizations in elderly Australians. In this study, which used convenience sampling, all admissions of elderly people to two hospitals in Tasmania ...
Kargar, Mona, Kheirollah Gholami, Ahmadvand, Alireza, Gholami, Kheirollah, Mona Kargar, Alireza Ahmadvand   +5 more
core   +1 more source

Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury

Frontiers in Pharmacology, 2019
Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug. Overdose of APAP is the leading cause of hospital admission for acute liver failure.
Shiyun Pu, Qinhui Liu, Yanping Li, Rui Li, Tong Wu, Zijing Zhang, Cuiyuan Huang, Xuping Yang, Jinhan He, Jinhan He   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source