Results 21 to 30 of about 592,211 (297)

The Role of Sirt6 in Obesity and Diabetes

Frontiers in Physiology, 2018
Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase and ADP-ribose transferase enzyme. It has an important role in physiological and pathological processes, regulating aging, cancer, obesity, insulin resistance ...
Jiangying Kuang, Jiangying Kuang, Lei Chen, Lei Chen, Qin Tang, Qin Tang, Jinhang Zhang, Jinhang Zhang, Yanping Li, Yanping Li, Jinhan He, Jinhan He   +11 more
doaj   +1 more source

Analysis of drug use in patients of analgesic nephropathy

National Journal of Physiology, Pharmacy and Pharmacology, 2022
Background: The global incidence and prevalence of analgesic nephropathy is 28% in 1981 and 12% in 1990. Intake of 6–8 tablets per day for 6–8 years attributes to development of analgesic nephropathy.
Inderpal Singh Grover, Deepa Latha C, Raja Vikram Prasad, Suvarchala Satyagama   +3 more
doaj   +1 more source

Refining adverse drug reaction signals by incorporating interaction variables identified using emergent pattern mining [PDF]

, 2016
Purpose: To develop a framework for identifying and incorporating candidate confounding interaction terms into a regularised cox regression analysis to refine adverse drug reaction signals obtained via longitudinal observational data.
Bien, Brookhart, Brooks, Caster, Chambless, Cox, Davies, Goldman, Hahsler, Hoerl, Härmark, Jenna M. Reps, Lewis, Li, McGue, McMahon, Pirmohamed, Reps, Reps, Reps, Richard B. Hubbard, Ryan, Scheiber, Schneeweiss, Schuemie, Shepherd, Simon, Spruance, Therneau, Tibshirani, Uwe Aickelin, van Puijenbroek, Wu, Zou   +33 more
core   +3 more sources

The concept of adverse drug reaction reporting: awareness among pharmacy students in a Nigerian university [PDF]

, 2013
Adverse drug reaction (ADR) is poorly reported globally but more in developing countries with poor participation by health professionals. Currently, there is no known literature on the Nigerian pharmacy students’ knowledge on ADR reporting.
Fakeye Titilayo Oyelola, Johnson Segun Showande   +1 more
core   +2 more sources

Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event. [PDF]

, 2016
BACKGROUND: Cetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but serious adverse events.
Baba-Hamed, N., Deplanque, G., Jardin-Szucs, M., Maritaz, C., Metz, C.   +4 more
core   +2 more sources

Factors influencing medical staff’ s understanding of correct use for adrenaline in the treatment of severe allergic reactions: a literature review [PDF]

Xin yixue
Objective To understand the cognitive influencing factors affecting the use of epinephrine by medical staff for the treatment of serve allergic reactions and the current state of research at home and abroad.
YANG Jia, WANG Yan, DENG Li, LI Wenjun, DU Qian, LIU Songqing, XI Xin
doaj   +1 more source

Investigation and analysis of food consumption of urban residents in 3 cities of Jiangxi Province in 2019

Zhongguo shipin weisheng zazhi, 2022
ObjectiveTo understand the dietary structure and nutrient intake of urban residents in 3 cities， food consumption in Jiangxi Province was investigated in 2019.MethodsA multi-stage stratified cluster random sampling method was used to select 1 251 ...
WU Hao, WU Lihua, LUO Wei, LU Keke, FU Junjie   +4 more
doaj   +1 more source

Signalling paediatric side effects using an ensemble of simple study designs [PDF]

, 2014
Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness.
Aickelin, U., Aickelin, U., Garibaldi, J.M., Garibaldi, J.M., Gibson, J.E., Gibson, J.E., Hubbard, R.B., Hubbard, R.B., Reps, J.M., Reps, J.M., Soria, D., Soria, D.   +11 more
core   +6 more sources

Safety Profile of Oxaliplatin in 3,687 Patients With Cancer in China: A Post-Marketing Surveillance Study

Frontiers in Oncology, 2021
BackgroundOxaliplatin (OXA), a third-generation platinum derivative, has become one of the main chemotherapeutic drugs for colorectal cancer and other cancers, but reports of adverse reactions are also increasing with the extensive application of OXA. In
Zaoqin Yu, Rui Huang, Li Zhao, Ximin Wang, Xiaofang Shangguan, Wei Li, Min Li, Xianguo Yin, Chengliang Zhang, Dong Liu   +9 more
doaj   +1 more source

Predictive Performance of Bayesian Methods to Forecast Vancomycin Concentration for Therapeutic Drug Monitoring in Critically Ill Pediatric Patients

Pharmaceutics
Background: This study aimed to evaluate different Bayesian algorithms and the first-order pharmacokinetics (PK) equation approach for forecasting vancomycin concentrations in critically ill pediatric patients and to identify influencing factors. Methods:
Ha T. Pham, Cuc T. Nguyen, Tien T. N. Nguyen, Linh H. Hoang, Minh N. Tran, Thao P. Nguyen, Tuan N. Do, Ha T. H. Nguyen, Anh H. Nguyen, Phuc H. Phan, Dien M. Tran, Hoa D. Vu   +11 more
doaj   +1 more source