Results 11 to 20 of about 592,211 (297)

Apigenin reduces the suppressive effect of exosomes derived from irritable bowel syndrome patients on the autophagy of human colon epithelial cells by promoting ATG14

World Journal of Surgical Oncology, 2023
Background Inflammatory bowel disease (IBS) is a chronic disorder of the gastrointestinal tract. Exosomes have been involved in various pathological processes including IBS. Apigenin has been reported to suppress inflammatory bowel disease (IBS). However,
Rui Fu, Saiyue Liu, Mingjin Zhu, Jiajie Zhu, Mingxian Chen   +4 more
doaj   +1 more source

Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Pharmaceutics, 2021
Background: Ceftazidime and imipenem have been increasingly used to treat Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) due to their extended-spectrum covering Pseudomonas aeruginosa.
Thu-Minh Nguyen, Thu-Hue Ngo, Anh-Quan Truong, Dinh-Hoa Vu, Dinh-Chi Le, Ngan-Binh Vu, Tuyet-Nga Can, Hoang-Anh Nguyen, Thu-Phuong Phan, Françoise Van Bambeke, Céline Vidaillac, Quy-Chau Ngo   +11 more
doaj   +1 more source

Drug-Related Deaths in China: An Analysis of a Spontaneous Reporting System

Frontiers in Pharmacology, 2022
Background: Adverse drug reactions with an outcome of death represent the most serious consequences and are inherently important for pharmacovigilance.
Haona Li, Jianxiong Deng, Peiming Yu, Xuequn Ren   +3 more
doaj   +1 more source

Drug-Induced Severe Cutaneous Adverse Reactions: Insights Into Clinical Presentation, Immunopathogenesis, Diagnostic Methods, Treatment, and Pharmacogenomics

Frontiers in Pharmacology, 2022
SCARs are rare and life-threatening hypersensitivity reactions. In general, the increased duration of hospital stays and the associated cost burden are common issues, and in the worst-case scenario, they can result in mortality.
Therdpong Tempark, Therdpong Tempark, Shobana John, Shobana John, Pawinee Rerknimitr, Pawinee Rerknimitr, Patompong Satapornpong, Patompong Satapornpong, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem   +13 more
doaj   +1 more source

Adverse reactions of amiodarone [PDF]

, 2019
Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo, Ciacciarelli, Marco, Colunga Biancatelli, Ruben Ml, Congedo, Viviana, Iuliano, Luigi, Polidoro, Alessandro   +5 more
core   +1 more source

Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling

Molecular Metabolism, 2020
Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established ...
Qin Tang, Yong Gao, Qinhui Liu, Xuping Yang, Tong Wu, Cuiyuan Huang, Ya Huang, Jinhang Zhang, Zijing Zhang, Rui Li, Shiyun Pu, Guorong Zhang, Yingnan Zhao, Jian Zhou, Hui Huang, Yanping Li, Wei Jiang, Yongsheng Chang, Jinhan He   +18 more
doaj   +1 more source

Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme [PDF]

, 2008
Observation of adverse drug reactions during drug development can cause closure of the whole programme. However, if association between the genotype and the risk of an adverse event is discovered, then it might suffice to exclude patients of certain ...
Breiman, Breslow, Dudbridge, Díaz-Uriarte, Efron, Fielding, Genkin, Graven, Hastie, Izmirlian, Kelly, Lindley, Park, Ripley, Roses, Roses, Tibshirani, Troyanskaya, Wille, Xiong, Yuan, Zaykin   +21 more
core   +1 more source

PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy

Frontiers in Pharmacology, 2019
Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used ...
Yanping Li, Ting Zhang, Qinhui Liu, Jinhan He, Jinhan He   +4 more
doaj   +1 more source

Learning lessons from adverse drug reactions in children [PDF]

, 2016
Drug toxicity is, unfortunately, a significant problem in children both in the hospital and in the community. Drug toxicity in children is different to that seen in adults.
Bodenstein, Bénard-Laribière, Giménez, Kearns, Phelps, Silverman, Starko, Zhang   +7 more
core   +2 more sources

Value of patch tests in clindamycin-related drug eruptions [PDF]

, 2011
Background. Patch tests help to confirm the aetiology of the cutaneous adverse drug reactions involving delayed hypersensitivity mechanisms, but the results vary with the pattern of skin reaction and the culprit drug. Objectives.
Brites, MM, Canelas, MM, Gonçalo, Margarida, Pereira, N, Santiago, F   +4 more
core   +1 more source