Results 51 to 60 of about 592,211 (297)

Unsupervised extraction of adverse drug reaction relationships [PDF]

, 2015
En este trabajo se presentan los resultados preliminares de una nueva técnica no supervisada para la extracción de relaciones entre medicamentos y efectos adversos.
Araujo Serna, Lourdes, Duque Fernández, Andrés, Martínez Romo, Juan   +2 more
core   +1 more source

Pharmacogenomics of statin-related myopathy:Meta-analysis of rare variants from whole-exome sequencing [PDF]

, 2019
AIMS:Statin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large.
Aaspollu, Anu, Ahmed, Ammar, Alfirevic, Ana, Baranova, Ekaterina V., Bis, Joshua C., Bloch, Katarzyna M., Boerwinkle, Eric, Bondon-Guitton, Emmanuelle, Brisson, Diane, Brody, Jennifer A., Carr, Daniel F., Chinoy, Hector, Conforti, Anita, Delrieu, Olivier, Eriksson, Niclas, Floyd, James S., Gallagher, Arlene M., Gaudet, Daniel, Gibbs, Richard A., Gregory, Richard, Hallberg, Pär, Heckbert, Susan R., Khoury, Etienne, Lapeyre-Mestre, Maryse, Liu, Xiaoming, Liu, Xuan, Magnusson, Patrik K. E., Maitland-van der Zee, Anke-Hilse, Maroteau, Cyrielle, McCarthy, Alun, McKeigue, Paul, Molokhia, Mariam, Morris, Andrew P., Morrison, Alanna C., Palmer, Colin A. N., Pirmohamed, Munir, Psaty, Bruce M., Rice, Kenneth M., Siddiqui, Moneeza K., Sitlani, Colleen M., Stricker, Bruno H., Tracy, Russell, van Staa, Tjeerd, Wadelius, Mia, Wiggins, Kerri L., Yue, Qun-Ying   +45 more
core   +7 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

JENIS – JENIS EFEK SAMPING PENGOBATAN OAT DAN ART PADA PASIEN DENGAN KOINFEKSI TB/HIV DI RSUP dr.KARIADI [PDF]

, 2016
Background : Tuberculosis (TB) in Indonesia is still ranked 2nd in the world and is a major cause of death in people living with HIV AIDS (PLWHA). To reduce the risk of death in patients coinfected with TB/HIV, World Health Organization (WHO) recommends ...
Kholis, Fathur Nur, Natalie, Josephine, Ngestiningsih, Dwi   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interactive exploration of population scale pharmacoepidemiology datasets

, 2020
Population-scale drug prescription data linked with adverse drug reaction (ADR) data supports the fitting of models large enough to detect drug use and ADR patterns that are not detectable using traditional methods on smaller datasets. However, detecting
Abadi M., Furu K., Salathé M., Ventola C. L., Wishart D. S.   +4 more
core   +1 more source

Furosemide-induced eruption of haemorrhagic bullae on the fingers [PDF]

, 2016
This article describes a man who developed severe haemorrhagic necrotizing blisters within 1 week of being started on regular furosemide. The lesions were confined to the fingers bilaterally and accompanied by severe swelling and loss of function.
Casha, Aaron, Manche, Alexander, Mizzi, Sean, Sladden, David   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cytomegalovirus infection initiates inflammatory bowel disease by activating a positive MyD88/NF-κB feedback loop in allogeneic skin transplantation mice

Virology Journal
Infection with the cytomegalovirus (CMV) is common. Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract. CMV infection is involved in IBD pathogenesis. The abnormal activation of myeloid differentiation
Ming-Xian Chen, Yu Chen, Rui Fu, Jie-Yi Wang, Sai-Yue Liu, Tang-Biao Shen   +5 more
doaj   +1 more source

Semi-Supervised Recurrent Neural Network for Adverse Drug Reaction Mention Extraction

, 2017
Social media is an useful platform to share health-related information due to its vast reach. This makes it a good candidate for public-health monitoring tasks, specifically for pharmacovigilance.
Gupta, Shashank, Palshikar, Girish, Pawar, Sachin, Ramrakhiyani, Nitin, Varma, Vasudeva   +4 more
core   +1 more source