Results 61 to 70 of about 585,342 (345)

Adverse drug effects monitoring of amlodipine in a tertiary care hospital [PDF]

, 2018
Background: Amlodipine have been widely used drug for the treatment of Hypertension. It has many beneficial effects and less side effects. But, only very few adverse effects of Amlodipine have been documented and many were not reported.
Kumar, C. Vinoth, Poornima, M., Venkateswaran, M.   +2 more
core   +2 more sources

Cytomegalovirus infection initiates inflammatory bowel disease by activating a positive MyD88/NF-κB feedback loop in allogeneic skin transplantation mice

Virology Journal
Infection with the cytomegalovirus (CMV) is common. Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract. CMV infection is involved in IBD pathogenesis. The abnormal activation of myeloid differentiation
Ming-Xian Chen, Yu Chen, Rui Fu, Jie-Yi Wang, Sai-Yue Liu, Tang-Biao Shen   +5 more
doaj   +1 more source

ADRNet: A Generalized Collaborative Filtering Framework Combining Clinical and Non-Clinical Data for Adverse Drug Reaction Prediction [PDF]

arXiv, 2023
Adverse drug reaction (ADR) prediction plays a crucial role in both health care and drug discovery for reducing patient mortality and enhancing drug safety. Recently, many studies have been devoted to effectively predict the drug-ADRs incidence rates. However, these methods either did not effectively utilize non-clinical data, i.e., physical, chemical,
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling

Molecular Metabolism, 2020
Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established ...
Qin Tang, Yong Gao, Qinhui Liu, Xuping Yang, Tong Wu, Cuiyuan Huang, Ya Huang, Jinhang Zhang, Zijing Zhang, Rui Li, Shiyun Pu, Guorong Zhang, Yingnan Zhao, Jian Zhou, Hui Huang, Yanping Li, Wei Jiang, Yongsheng Chang, Jinhan He   +18 more
doaj  

Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh’s National Kala-azar Elimination Programme

Infectious Diseases of Poverty, 2018
Background Adverse effects of antileishmanial drugs can affect patients’ quality of life and adherence to therapy for visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL).
Md. Sakhawat Hossain, Amresh Kumar, A.F.M Akhtar Hossain, Md. Mahshin, Abhijit Sharma, Md. Akter Hossain, Varun Sharma, Rashidul Haque, A.K.M Shamsuzzaman, Shomik Maruf, Prakash Ghosh, Vivek Ahuja, Dinesh Mondal   +12 more
doaj   +1 more source

Assessment of knowledge, practices, and barriers to pharmacovigilance among nurses at a teaching hospital, Ghana: a cross‑sectional study

BMC Nursing, 2022
Background Pharmacovigilance may be defined as the continuous monitoring of the reaction between a drug agent or combination of drugs a patient took and steps taken to prevent any associated risk.
Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah, Joseph Ocansey, Aliu Moomin, Bright Owusu Danso, Frank Agyapong, Reginald Arthur-Mensah Jnr   +6 more
doaj   +1 more source

Rational Organisation of Adverse Drug Reaction Monitoring

Безопасность и риск фармакотерапии, 2022
The main pharmacoepidemiological method for assessing the efficacy and safety of ongoing pharmacotherapy involves the collection of spontaneous reports on adverse drug reactions (ADRs) associated with the use of medicines.The aim of the study was to ...
L. V. Shukil, S. G. Fominykh, V. A. Akhmedov, T. E. Perepichkina   +3 more
doaj   +1 more source

Biomarkers of adverse drug reactions [PDF]

Experimental Biology and Medicine, 2017
Adverse drug reactions can be caused by a wide range of therapeutics. Adverse drug reactions affect many bodily organ systems and vary widely in severity. Milder adverse drug reactions often resolve quickly following withdrawal of the casual drug or sometimes after dose reduction.
Daniel F Carr, Munir Pirmohamed
openaire   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source